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SE translation mRNA overexpression: a potential prognostic predictor in breast cancer

BACKGROUND: Patient SE translation (SET) belongs to histone chaperone nucleosome assembly protein family and has been confirmed that it is associated with carcinogenesis, tumor progression and patient outcome. In this study, we aim at assessing the prognostic value of SET mRNA, the function and path...

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Autores principales: Du, Qian, Hao, Ruifang, Liu, Leichao, Liu, Yang, Chen, Siying, You, Haisheng, Zhang, Ying, Dong, Yalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799295/
https://www.ncbi.nlm.nih.gov/pubmed/35116953
http://dx.doi.org/10.21037/tcr.2019.09.11
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author Du, Qian
Hao, Ruifang
Liu, Leichao
Liu, Yang
Chen, Siying
You, Haisheng
Zhang, Ying
Dong, Yalin
author_facet Du, Qian
Hao, Ruifang
Liu, Leichao
Liu, Yang
Chen, Siying
You, Haisheng
Zhang, Ying
Dong, Yalin
author_sort Du, Qian
collection PubMed
description BACKGROUND: Patient SE translation (SET) belongs to histone chaperone nucleosome assembly protein family and has been confirmed that it is associated with carcinogenesis, tumor progression and patient outcome. In this study, we aim at assessing the prognostic value of SET mRNA, the function and pathway of SET and its related genes in breast cancer. METHODS: The clinicopathological and prognostic significance of SET was assessed by the molecular taxonomy of breast cancer international consortium (METABRIC) database (n=1,904). Additionally, based on the data and network of SET and its related genes from cBioPortal website, their function in the progression of breast cancer was also explored. RESULTS: SET mRNA overexpression was a significant predictor of a poor prognosis (P=0.0006). The two signaling pathways associated with SET were the facilitating function of condensin II on mitosis and the accelerated transportation of tumor cell mRNA towards the extranuclear position, and SET acted to suppress condensin II and stabilize mRNA. CONCLUSIONS: Owing to the regulation of chromosome condensation and stabilization of tumor cell mRNA, overexpression of SET is correlated with aggressive phenotypes and facilitates tumor proliferation and deterioration. SET may act as a valuable prognosis biomarker in breast cancer.
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spelling pubmed-87992952022-02-02 SE translation mRNA overexpression: a potential prognostic predictor in breast cancer Du, Qian Hao, Ruifang Liu, Leichao Liu, Yang Chen, Siying You, Haisheng Zhang, Ying Dong, Yalin Transl Cancer Res Original Article BACKGROUND: Patient SE translation (SET) belongs to histone chaperone nucleosome assembly protein family and has been confirmed that it is associated with carcinogenesis, tumor progression and patient outcome. In this study, we aim at assessing the prognostic value of SET mRNA, the function and pathway of SET and its related genes in breast cancer. METHODS: The clinicopathological and prognostic significance of SET was assessed by the molecular taxonomy of breast cancer international consortium (METABRIC) database (n=1,904). Additionally, based on the data and network of SET and its related genes from cBioPortal website, their function in the progression of breast cancer was also explored. RESULTS: SET mRNA overexpression was a significant predictor of a poor prognosis (P=0.0006). The two signaling pathways associated with SET were the facilitating function of condensin II on mitosis and the accelerated transportation of tumor cell mRNA towards the extranuclear position, and SET acted to suppress condensin II and stabilize mRNA. CONCLUSIONS: Owing to the regulation of chromosome condensation and stabilization of tumor cell mRNA, overexpression of SET is correlated with aggressive phenotypes and facilitates tumor proliferation and deterioration. SET may act as a valuable prognosis biomarker in breast cancer. AME Publishing Company 2019-09 /pmc/articles/PMC8799295/ /pubmed/35116953 http://dx.doi.org/10.21037/tcr.2019.09.11 Text en 2019 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Original Article
Du, Qian
Hao, Ruifang
Liu, Leichao
Liu, Yang
Chen, Siying
You, Haisheng
Zhang, Ying
Dong, Yalin
SE translation mRNA overexpression: a potential prognostic predictor in breast cancer
title SE translation mRNA overexpression: a potential prognostic predictor in breast cancer
title_full SE translation mRNA overexpression: a potential prognostic predictor in breast cancer
title_fullStr SE translation mRNA overexpression: a potential prognostic predictor in breast cancer
title_full_unstemmed SE translation mRNA overexpression: a potential prognostic predictor in breast cancer
title_short SE translation mRNA overexpression: a potential prognostic predictor in breast cancer
title_sort se translation mrna overexpression: a potential prognostic predictor in breast cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799295/
https://www.ncbi.nlm.nih.gov/pubmed/35116953
http://dx.doi.org/10.21037/tcr.2019.09.11
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