Endovascular Management of Mucormycotic Aneurysms of the Internal Carotid Artery in Post-COVID-19 Patients

The repercussions of the coronavirus disease 2019 (COVID-19) are being felt throughout the world to this day. India is one such country ravaged by the second wave of the pandemic. Here, we report two cases of post-COVID-19 mucormycotic aneurysm of the internal carotid artery (ICA), which we believe are the first of their kind in the reported medical literature. A nasopharyngeal swab for reverse-transcriptase polymerase chain reaction of the severe acute respiratory syndrome coronavirus 2 was positive for both cases. After recovering from COVID-19, both patients developed signs and symptoms suggestive of mucormycosis, which were confirmed by a fungal smear. They were managed with liposomal amphotericin B (LAmB) and other adjunctive medicines. The first patient developed a massive bout of epistaxis during surgical debulking of his fungal mass. He underwent anterior nasal packing and emergency digital subtraction angiogram which revealed an aneurysm of the right ICA which was treated by coiling of the aneurysm and parent artery occlusion of the right ICA. The second patient had a history of post-COVID-19 mucormycosis which was managed by LAmB, surgical debulking, and posaconazole. He was not in regular follow-up and did not fully complete his antifungal therapy. Later, he presented with recurrent episodes of epistaxis followed by a massive bout of bleeding from both nostrils which upon evaluation revealed a thin-walled aneurysm of the left cavernous ICA. He was treated with flow diversion and coiling. Both patients responded well and the aneurysms were successfully excluded from the circulation. Their follow-ups were uneventful.