Drug Interactions Affecting Kidney Function: Beware of Health Threats from Triple Whammy

Triple whammy (TW) is a potentially dangerous drug combination that can lead to acute kidney injury (AKI). This drug interaction (DI) occurs when angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) are used together with diuretics and non-steroidal anti-inflam...

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Autores principales: Harężlak, Tomasz, Religioni, Urszula, Szymański, Filip M., Hering, Dagmara, Barańska, Agnieszka, Neumann-Podczaska, Agnieszka, Allan, Matthew, Merks, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799554/
https://www.ncbi.nlm.nih.gov/pubmed/34845649
http://dx.doi.org/10.1007/s12325-021-01939-9
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author Harężlak, Tomasz
Religioni, Urszula
Szymański, Filip M.
Hering, Dagmara
Barańska, Agnieszka
Neumann-Podczaska, Agnieszka
Allan, Matthew
Merks, Piotr
author_facet Harężlak, Tomasz
Religioni, Urszula
Szymański, Filip M.
Hering, Dagmara
Barańska, Agnieszka
Neumann-Podczaska, Agnieszka
Allan, Matthew
Merks, Piotr
author_sort Harężlak, Tomasz
collection PubMed
description Triple whammy (TW) is a potentially dangerous drug combination that can lead to acute kidney injury (AKI). This drug interaction (DI) occurs when angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) are used together with diuretics and non-steroidal anti-inflammatory drugs (NSAIDs). One of the most serious consequences of TW DI is an increased risk of developing pre-renal acute kidney injury (pr-AKI). The term TW, in the context of a DI affecting kidney function, is not very widespread. The aim of this article was to gather information on this interaction. Previous knowledge on the mechanism of TW and how to increase patient awareness of this interaction is described. In addition, the specific nature of the acute kidney injury (AKI) caused by triple whammy (AKITW) is presented. On the basis of the current state of knowledge, recommendations on how to manage the TW DI are also demonstrated.
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spelling pubmed-87995542022-02-02 Drug Interactions Affecting Kidney Function: Beware of Health Threats from Triple Whammy Harężlak, Tomasz Religioni, Urszula Szymański, Filip M. Hering, Dagmara Barańska, Agnieszka Neumann-Podczaska, Agnieszka Allan, Matthew Merks, Piotr Adv Ther Review Triple whammy (TW) is a potentially dangerous drug combination that can lead to acute kidney injury (AKI). This drug interaction (DI) occurs when angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) are used together with diuretics and non-steroidal anti-inflammatory drugs (NSAIDs). One of the most serious consequences of TW DI is an increased risk of developing pre-renal acute kidney injury (pr-AKI). The term TW, in the context of a DI affecting kidney function, is not very widespread. The aim of this article was to gather information on this interaction. Previous knowledge on the mechanism of TW and how to increase patient awareness of this interaction is described. In addition, the specific nature of the acute kidney injury (AKI) caused by triple whammy (AKITW) is presented. On the basis of the current state of knowledge, recommendations on how to manage the TW DI are also demonstrated. Springer Healthcare 2021-11-29 2022 /pmc/articles/PMC8799554/ /pubmed/34845649 http://dx.doi.org/10.1007/s12325-021-01939-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Harężlak, Tomasz
Religioni, Urszula
Szymański, Filip M.
Hering, Dagmara
Barańska, Agnieszka
Neumann-Podczaska, Agnieszka
Allan, Matthew
Merks, Piotr
Drug Interactions Affecting Kidney Function: Beware of Health Threats from Triple Whammy
title Drug Interactions Affecting Kidney Function: Beware of Health Threats from Triple Whammy
title_full Drug Interactions Affecting Kidney Function: Beware of Health Threats from Triple Whammy
title_fullStr Drug Interactions Affecting Kidney Function: Beware of Health Threats from Triple Whammy
title_full_unstemmed Drug Interactions Affecting Kidney Function: Beware of Health Threats from Triple Whammy
title_short Drug Interactions Affecting Kidney Function: Beware of Health Threats from Triple Whammy
title_sort drug interactions affecting kidney function: beware of health threats from triple whammy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799554/
https://www.ncbi.nlm.nih.gov/pubmed/34845649
http://dx.doi.org/10.1007/s12325-021-01939-9
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