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Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle

Tendon rupture and nerve injury cause fatty infiltration of the skeletal muscle, and the adipokines secreted from the infiltrated adipocytes are known to contribute to chronic inflammation. Therefore, in this study, we evaluated the effects of the adipokines on chronic inflammation using a rat sciat...

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Autores principales: Shinohara, Issei, Kataoka, Takeshi, Mifune, Yutaka, Inui, Atsuyuki, Sakata, Ryosuke, Nishimoto, Hanako, Yamaura, Kohei, Mukohara, Shintaro, Yoshikawa, Tomoya, Kato, Tatsuo, Furukawa, Takahiro, Matsushita, Takehiko, Kuroda, Ryosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799651/
https://www.ncbi.nlm.nih.gov/pubmed/35091650
http://dx.doi.org/10.1038/s41598-022-05608-x
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author Shinohara, Issei
Kataoka, Takeshi
Mifune, Yutaka
Inui, Atsuyuki
Sakata, Ryosuke
Nishimoto, Hanako
Yamaura, Kohei
Mukohara, Shintaro
Yoshikawa, Tomoya
Kato, Tatsuo
Furukawa, Takahiro
Matsushita, Takehiko
Kuroda, Ryosuke
author_facet Shinohara, Issei
Kataoka, Takeshi
Mifune, Yutaka
Inui, Atsuyuki
Sakata, Ryosuke
Nishimoto, Hanako
Yamaura, Kohei
Mukohara, Shintaro
Yoshikawa, Tomoya
Kato, Tatsuo
Furukawa, Takahiro
Matsushita, Takehiko
Kuroda, Ryosuke
author_sort Shinohara, Issei
collection PubMed
description Tendon rupture and nerve injury cause fatty infiltration of the skeletal muscle, and the adipokines secreted from the infiltrated adipocytes are known to contribute to chronic inflammation. Therefore, in this study, we evaluated the effects of the adipokines on chronic inflammation using a rat sciatic nerve-crushed injury model. In vitro and in vivo experiments showed that the expression of adiponectin was decreased (0.3-fold) and the expression of Il6 (~ 3.8-fold) and Tnf (~ 6.2-fold) was increased in the nerve-crushed group compared to that in the control group. It was also observed that the administration of an adiponectin receptor agonist decreased the levels of Il6 (0.38-fold) and Tnf (0.28-fold) and improved cellular viability (~ 1.9-fold) in vitro. Additionally, in the fatty infiltrated skeletal muscle, low adiponectin levels were found to be associated with chronic inflammation. Therefore, the local administration of adiponectin receptor agonists would prevent chronic inflammation.
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spelling pubmed-87996512022-02-01 Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle Shinohara, Issei Kataoka, Takeshi Mifune, Yutaka Inui, Atsuyuki Sakata, Ryosuke Nishimoto, Hanako Yamaura, Kohei Mukohara, Shintaro Yoshikawa, Tomoya Kato, Tatsuo Furukawa, Takahiro Matsushita, Takehiko Kuroda, Ryosuke Sci Rep Article Tendon rupture and nerve injury cause fatty infiltration of the skeletal muscle, and the adipokines secreted from the infiltrated adipocytes are known to contribute to chronic inflammation. Therefore, in this study, we evaluated the effects of the adipokines on chronic inflammation using a rat sciatic nerve-crushed injury model. In vitro and in vivo experiments showed that the expression of adiponectin was decreased (0.3-fold) and the expression of Il6 (~ 3.8-fold) and Tnf (~ 6.2-fold) was increased in the nerve-crushed group compared to that in the control group. It was also observed that the administration of an adiponectin receptor agonist decreased the levels of Il6 (0.38-fold) and Tnf (0.28-fold) and improved cellular viability (~ 1.9-fold) in vitro. Additionally, in the fatty infiltrated skeletal muscle, low adiponectin levels were found to be associated with chronic inflammation. Therefore, the local administration of adiponectin receptor agonists would prevent chronic inflammation. Nature Publishing Group UK 2022-01-28 /pmc/articles/PMC8799651/ /pubmed/35091650 http://dx.doi.org/10.1038/s41598-022-05608-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Shinohara, Issei
Kataoka, Takeshi
Mifune, Yutaka
Inui, Atsuyuki
Sakata, Ryosuke
Nishimoto, Hanako
Yamaura, Kohei
Mukohara, Shintaro
Yoshikawa, Tomoya
Kato, Tatsuo
Furukawa, Takahiro
Matsushita, Takehiko
Kuroda, Ryosuke
Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle
title Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle
title_full Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle
title_fullStr Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle
title_full_unstemmed Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle
title_short Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle
title_sort influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799651/
https://www.ncbi.nlm.nih.gov/pubmed/35091650
http://dx.doi.org/10.1038/s41598-022-05608-x
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