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Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder
Although fatigue is a major symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), the underlying mechanism remains unclear. We explored the relationship between subcortical structures and fatigue severity to identify neural substrates of fatigue in NMOSD. Clinical characteristics...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799731/ https://www.ncbi.nlm.nih.gov/pubmed/35091634 http://dx.doi.org/10.1038/s41598-022-05531-1 |
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author | Seok, Jin Myoung Cho, Wanzee Son, Doo-Hwan Shin, Jong Hwa Cho, Eun Bin Kim, Sung Tae Kim, Byoung Joon Seong, Joon-Kyung Min, Ju-Hong |
author_facet | Seok, Jin Myoung Cho, Wanzee Son, Doo-Hwan Shin, Jong Hwa Cho, Eun Bin Kim, Sung Tae Kim, Byoung Joon Seong, Joon-Kyung Min, Ju-Hong |
author_sort | Seok, Jin Myoung |
collection | PubMed |
description | Although fatigue is a major symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), the underlying mechanism remains unclear. We explored the relationship between subcortical structures and fatigue severity to identify neural substrates of fatigue in NMOSD. Clinical characteristics with brain magnetic resonance imaging were evaluated in forty patients with NMOSD. Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-fatigue) questionnaire (a higher score indicates less fatigue). We assessed the correlation between subcortical structures and fatigue severity using surface-based shape analysis. Most of the enrolled patients showed fatigue (72.5%; mean FACIT-fatigue score, 34.8 ± 10.8). The FACIT-fatigue score was negatively correlated with Expanded Disability Status Scale and Beck Depression Inventory scores (r = − 0.382, p = 0.016; r = − 0.578, p < 0.001). We observed that the right thalamus was the only extracted region for various threshold experiments. Further, patients with lower FACIT-fatigue scores (more fatigue) had decreased local shape volume in the right thalamus. Fatigue is common in patients with NMOSD, and atrophy in the right thalamus is strongly correlated with fatigue severity. The local shape volume of the right thalamus might serve as a biomarker of fatigue in NMOSD. |
format | Online Article Text |
id | pubmed-8799731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-87997312022-02-01 Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder Seok, Jin Myoung Cho, Wanzee Son, Doo-Hwan Shin, Jong Hwa Cho, Eun Bin Kim, Sung Tae Kim, Byoung Joon Seong, Joon-Kyung Min, Ju-Hong Sci Rep Article Although fatigue is a major symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), the underlying mechanism remains unclear. We explored the relationship between subcortical structures and fatigue severity to identify neural substrates of fatigue in NMOSD. Clinical characteristics with brain magnetic resonance imaging were evaluated in forty patients with NMOSD. Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-fatigue) questionnaire (a higher score indicates less fatigue). We assessed the correlation between subcortical structures and fatigue severity using surface-based shape analysis. Most of the enrolled patients showed fatigue (72.5%; mean FACIT-fatigue score, 34.8 ± 10.8). The FACIT-fatigue score was negatively correlated with Expanded Disability Status Scale and Beck Depression Inventory scores (r = − 0.382, p = 0.016; r = − 0.578, p < 0.001). We observed that the right thalamus was the only extracted region for various threshold experiments. Further, patients with lower FACIT-fatigue scores (more fatigue) had decreased local shape volume in the right thalamus. Fatigue is common in patients with NMOSD, and atrophy in the right thalamus is strongly correlated with fatigue severity. The local shape volume of the right thalamus might serve as a biomarker of fatigue in NMOSD. Nature Publishing Group UK 2022-01-28 /pmc/articles/PMC8799731/ /pubmed/35091634 http://dx.doi.org/10.1038/s41598-022-05531-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Seok, Jin Myoung Cho, Wanzee Son, Doo-Hwan Shin, Jong Hwa Cho, Eun Bin Kim, Sung Tae Kim, Byoung Joon Seong, Joon-Kyung Min, Ju-Hong Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder |
title | Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder |
title_full | Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder |
title_fullStr | Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder |
title_full_unstemmed | Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder |
title_short | Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder |
title_sort | association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799731/ https://www.ncbi.nlm.nih.gov/pubmed/35091634 http://dx.doi.org/10.1038/s41598-022-05531-1 |
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