Cargando…

Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease

MATα1 catalyzes the synthesis of S-adenosylmethionine, the principal biological methyl donor. Lower MATα1 activity and mitochondrial dysfunction occur in alcohol-associated liver disease. Besides cytosol and nucleus, MATα1 also targets the mitochondria of hepatocytes to regulate their function. Here...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barbier-Torres, Lucía, Murray, Ben, Yang, Jin Won, Wang, Jiaohong, Matsuda, Michitaka, Robinson, Aaron, Binek, Aleksandra, Fan, Wei, Fernández-Ramos, David, Lopitz-Otsoa, Fernando, Luque-Urbano, Maria, Millet, Oscar, Mavila, Nirmala, Peng, Hui, Ramani, Komal, Gottlieb, Roberta, Sun, Zhaoli, Liangpunsakul, Suthat, Seki, Ekihiro, Van Eyk, Jennifer E., Mato, Jose M., Lu, Shelly C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799735/ https://www.ncbi.nlm.nih.gov/pubmed/35091576 http://dx.doi.org/10.1038/s41467-022-28201-2

Ejemplares similares

Role of Methionine Adenosyltransferase Genes in Hepatocarcinogenesis
por: Ramani, Komal, et al.
Publicado: (2011)

Methionine adenosyltransferases in liver cancer
por: Murray, Ben, et al.
Publicado: (2019)

Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells
por: Tomasi, Maria Lauda, et al.
Publicado: (2015)

Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models
por: Ramani, Komal, et al.
Publicado: (2022)

Correction: Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models
por: Ramani, Komal, et al.
Publicado: (2023)

Implications of divergence of methionine adenosyltransferase in archaea
por: Chouhan, Bhanu Pratap Singh, et al.
Publicado: (2021)

Prohibitin 1 Acts As a Negative Regulator of Wingless/Integrated‐Beta‐Catenin Signaling in Murine Liver and Human Liver Cancer Cells
por: Mavila, Nirmala, et al.
Publicado: (2018)

The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases
por: Pérez, Claudia, et al.
Publicado: (2016)

Hyperphosphorylation of hepatic proteome characterizes nonalcoholic fatty liver disease in S-adenosylmethionine deficiency
por: Robinson, Aaron E., et al.
Publicado: (2023)

Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis
por: Berger, Bradley J, et al.
Publicado: (2003)

Structural and functional characterisation of the methionine adenosyltransferase from Thermococcus kodakarensis
por: Schlesier, Julia, et al.
Publicado: (2013)

Correction: The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases
por: Pérez, Claudia, et al.
Publicado: (2016)

Methionine Adenosyltransferase I/III Deficiency Detected by Newborn Screening
por: Hübner, Vanessa, et al.
Publicado: (2022)

Impact of glutathione supplementation of parenteral nutrition on hepatic methionine adenosyltransferase activity
por: Elremaly, Wesam, et al.
Publicado: (2015)

Substrate Dynamics Contribute to Enzymatic Specificity in Human and Bacterial Methionine Adenosyltransferases
por: Gade, Madhuri, et al.
Publicado: (2021)

Evolution of homo‐oligomerization of methionine S‐adenosyltransferases is replete with structure–function constrains
por: Kleiner, Daniel, et al.
Publicado: (2022)

Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells
por: Phuong, Nguyen Thi Thuy, et al.
Publicado: (2015)

Methionine adenosyltransferase I/III deficiency: beyond the central nervous system manifestations
por: Nashabat, Marwan, et al.
Publicado: (2018)

SAMase of Bacteriophage T3 Inactivates Escherichia coli’s Methionine S-Adenosyltransferase by Forming Heteropolymers
por: Simon-Baram, Hadas, et al.
Publicado: (2021)

Correction to “Substrate Dynamics Contribute to Enzymatic Specificity in Human and Bacterial Methionine Adenosyltransferases”
por: Gade, Madhuri, et al.
Publicado: (2022)

S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis
por: Tomasi, Maria Lauda, et al.
Publicado: (2017)

2′,6′-Dihalostyrylanilines, Pyridines, and Pyrimidines for the Inhibition of the Catalytic Subunit of Methionine S-Adenosyltransferase-2
por: Sviripa, Vitaliy M., et al.
Publicado: (2014)

Polar Interactions at the Dimer–Dimer Interface of Methionine Adenosyltransferase MAT I Control Tetramerization
por: Sánchez-Pérez, Gabino Francisco, et al.
Publicado: (2021)

Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits
por: Shafqat, Naeem, et al.
Publicado: (2013)

Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis
por: Wang, Xuliang, et al.
Publicado: (2014)

Role of methionine adenosyltransferase 2A in bovine preimplantation development and its associated genomic regions
por: Ikeda, Shuntaro, et al.
Publicado: (2017)

Long-term prognosis of 35 patients with methionine adenosyltransferase deficiency based on newborn screening in China
por: Tong, Fan, et al.
Publicado: (2023)

NADP(+) Binding to the Regulatory Subunit of Methionine Adenosyltransferase II Increases Intersubunit Binding Affinity in the Hetero-Trimer
por: González, Beatriz, et al.
Publicado: (2012)

Biosynthesis of S-Adenosylmethionine by Magnetically Immobilized Escherichia coli Cells Highly Expressing a Methionine Adenosyltransferase Variant
por: Yin, Chunli, et al.
Publicado: (2017)

Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes
por: Bai, Jing, et al.
Publicado: (2018)

mTORC1-independent translation control in mammalian cells by methionine adenosyltransferase 2A and S-adenosylmethionine
por: Alam, Mahabub, et al.
Publicado: (2022)

Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle
por: Rajabian, Nika, et al.
Publicado: (2023)

One Carbon Metabolism and S-Adenosylmethionine in Non-Alcoholic Fatty Liver Disease Pathogenesis and Subtypes
por: Fernández-Ramos, David, et al.
Publicado: (2022)

Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis
por: Sáenz de Urturi, Diego, et al.
Publicado: (2022)

The X Protein of Hepatitis B Virus Inhibits Apoptosis in Hepatoma Cells through Enhancing the Methionine Adenosyltransferase 2A Gene Expression and Reducing S-Adenosylmethionine Production
por: Liu, Quanyan, et al.
Publicado: (2011)

Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice
por: Martin, Kelly A., et al.
Publicado: (2019)

Therapeutic Targeting of Fumaryl Acetoacetate Hydrolase in Hereditary Tyrosinemia Type I
por: Gil-Martínez, Jon, et al.
Publicado: (2021)

Post-translational modifiers of liver kinase B1/serine/threonine kinase 11 in hepatocellular carcinoma
por: Delgado, Teresa Cardoso, et al.
Publicado: (2019)

MicroRNA-21-3p, a Berberine-Induced miRNA, Directly Down-Regulates Human Methionine Adenosyltransferases 2A and 2B and Inhibits Hepatoma Cell Growth
por: Lo, Ting-Fang, et al.
Publicado: (2013)

Anaplastic Large Cell Lymphoma and Vanishing Bile Duct Syndrome
por: Sreepati, Gouri, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_7la0on1rmbj25g8a86f5mvj1ua