DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis

Gastrointestinal mucositis is one of the most debilitating side effects of the chemotherapeutic agent irinotecan (CPT-11). Andrographolide, a natural bicyclic diterpenoid lactone, has been reported to possess anti-colitis activity. In this study, andrographolide treatment was found to significantly...

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Detalles Bibliográficos
Autores principales: Wang, Yuanyuan, Wei, Bin, Wang, Danping, Wu, Jingjing, Gao, Jianhua, Zhong, Haiqing, Sun, Yang, Xu, Qiang, Liu, Wen, Gu, Yanhong, Guo, Wenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799857/
https://www.ncbi.nlm.nih.gov/pubmed/35127384
http://dx.doi.org/10.1016/j.apsb.2021.03.043

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