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Evaluation of ocular psoriasis with meibography()

BACKGROUND: Previous studies has shown that dry eye test abnormalities, meibomian gland dysfunction (MGD), may occur in psoriasis. OBJECTIVES: The authors aimed to evaluate the dry eye disease (DED), MGD, in psoriasis patients with meibography which is a current, objective, noninvasive method for pa...

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Autores principales: Kemeriz, Funda, Tugrul, Burcu, Yasar, Erdogan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799865/
https://www.ncbi.nlm.nih.gov/pubmed/34785066
http://dx.doi.org/10.1016/j.abd.2021.05.008
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author Kemeriz, Funda
Tugrul, Burcu
Yasar, Erdogan
author_facet Kemeriz, Funda
Tugrul, Burcu
Yasar, Erdogan
author_sort Kemeriz, Funda
collection PubMed
description BACKGROUND: Previous studies has shown that dry eye test abnormalities, meibomian gland dysfunction (MGD), may occur in psoriasis. OBJECTIVES: The authors aimed to evaluate the dry eye disease (DED), MGD, in psoriasis patients with meibography which is a current, objective, noninvasive method for patients with meibomian gland diseases, to investigate the relationship between disease severity and ocular involvement. METHODS: This study included 50 participants with psoriasis and 50 healthy individuals. All subjects were examined by the same dermatologist and referred for ophthalmological examination including meibomian gland obstruction, lid margin alterations assessment, ocular surface disease index assessment, tear film break-up time test, Schirmer test, corneal conjunctival fluorescein staining assessment. Additionally, upper and lower lids were evaluated for meibomian gland loss with meibography. RESULTS: MGD (28%), meibomian gland loss (MGL) (29.5%), upper meiboscore (0.61 ± 0.81), lower meiboscore (0.46 ± 0.61), DED (22%) were significantly higher in the psoriasis group compared with the control group (p = 0.008, p < 0.001, p = 0.027, p = 0.041, p = 0.044, respectively). There was a significant relationship between MGD and psoriasis area severity index (PASI) (p = 0.015, Odds Ratio = 1.211). There was a significant positive relationship between MGL with PASI (p < 0.001, r = 608) and psoriasis duration (p < 0.001, r = 0.547). STUDY LIMITATIONS: Smaller study group and inability to detect quality changes of meibum with meibography were limitations of the study. CONCLUSIONS: Psoriasis may affect the meibomian gland morphology, may cause structural changes in meibomian glands, and as a result of these may cause MGD and DED. Therefore, ophthalmologists and dermatologists should be aware of this situation and co-evaluate the patients in this respect.
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spelling pubmed-87998652022-02-03 Evaluation of ocular psoriasis with meibography() Kemeriz, Funda Tugrul, Burcu Yasar, Erdogan An Bras Dermatol Original Article BACKGROUND: Previous studies has shown that dry eye test abnormalities, meibomian gland dysfunction (MGD), may occur in psoriasis. OBJECTIVES: The authors aimed to evaluate the dry eye disease (DED), MGD, in psoriasis patients with meibography which is a current, objective, noninvasive method for patients with meibomian gland diseases, to investigate the relationship between disease severity and ocular involvement. METHODS: This study included 50 participants with psoriasis and 50 healthy individuals. All subjects were examined by the same dermatologist and referred for ophthalmological examination including meibomian gland obstruction, lid margin alterations assessment, ocular surface disease index assessment, tear film break-up time test, Schirmer test, corneal conjunctival fluorescein staining assessment. Additionally, upper and lower lids were evaluated for meibomian gland loss with meibography. RESULTS: MGD (28%), meibomian gland loss (MGL) (29.5%), upper meiboscore (0.61 ± 0.81), lower meiboscore (0.46 ± 0.61), DED (22%) were significantly higher in the psoriasis group compared with the control group (p = 0.008, p < 0.001, p = 0.027, p = 0.041, p = 0.044, respectively). There was a significant relationship between MGD and psoriasis area severity index (PASI) (p = 0.015, Odds Ratio = 1.211). There was a significant positive relationship between MGL with PASI (p < 0.001, r = 608) and psoriasis duration (p < 0.001, r = 0.547). STUDY LIMITATIONS: Smaller study group and inability to detect quality changes of meibum with meibography were limitations of the study. CONCLUSIONS: Psoriasis may affect the meibomian gland morphology, may cause structural changes in meibomian glands, and as a result of these may cause MGD and DED. Therefore, ophthalmologists and dermatologists should be aware of this situation and co-evaluate the patients in this respect. Sociedade Brasileira de Dermatologia 2022 2021-11-14 /pmc/articles/PMC8799865/ /pubmed/34785066 http://dx.doi.org/10.1016/j.abd.2021.05.008 Text en © 2021 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Kemeriz, Funda
Tugrul, Burcu
Yasar, Erdogan
Evaluation of ocular psoriasis with meibography()
title Evaluation of ocular psoriasis with meibography()
title_full Evaluation of ocular psoriasis with meibography()
title_fullStr Evaluation of ocular psoriasis with meibography()
title_full_unstemmed Evaluation of ocular psoriasis with meibography()
title_short Evaluation of ocular psoriasis with meibography()
title_sort evaluation of ocular psoriasis with meibography()
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799865/
https://www.ncbi.nlm.nih.gov/pubmed/34785066
http://dx.doi.org/10.1016/j.abd.2021.05.008
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