Discovery of novel 4-phenylquinazoline-based BRD4 inhibitors for cardiac fibrosis

Bromodomain containing protein 4 (BRD4), as an epigenetic reader, can specifically bind to the acetyl lysine residues of histones and has emerged as an attractive therapeutic target for various diseases, including cancer, cardiac remodeling and heart failure. Herein, we described the discovery of hi...

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Detalles Bibliográficos
Autores principales: He, Zhangxu, Jiao, Haomiao, An, Qi, Zhang, Xin, Zengyangzong, Dan, Xu, Jiale, Liu, Hongmin, Ma, Liying, Zhao, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799877/
https://www.ncbi.nlm.nih.gov/pubmed/35127386
http://dx.doi.org/10.1016/j.apsb.2021.07.018

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