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Discovery of novel KRAS‒PDEδ inhibitors with potent activity in patient-derived human pancreatic tumor xenograft models

KRAS‒PDEδ interaction is revealed as a promising target for suppressing the function of mutant KRAS. The bottleneck in clinical development of PDEδ inhibitors is the poor antitumor activity of known chemotypes. Here, we identified novel spiro-cyclic PDEδ inhibitors with potent antitumor activity bot...

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Detalles Bibliográficos
Autores principales:	Chen, Long, Zhang, Jing, Wang, Xinjing, Li, Yu, Zhou, Lu, Lu, Xiongxiong, Dong, Guoqiang, Sheng, Chunquan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799878/ https://www.ncbi.nlm.nih.gov/pubmed/35127385 http://dx.doi.org/10.1016/j.apsb.2021.07.009

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