Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling

The first rate-limiting enzyme of the serine synthesis pathway (SSP), phosphoglycerate dehydrogenase (PHGDH), is hyperactive in multiple tumors, which leads to the activation of SSP and promotes tumorigenesis. However, only a few inhibitors of PHGDH have been discovered to date, especially the coval...

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Detalles Bibliográficos
Autores principales: Chen, Chen, Zhu, Tianyu, Liu, Xiaoqin, Zhu, Dongrong, Zhang, Yi, Wu, Sifang, Han, Chao, Zhang, Hao, Luo, Jianguang, Kong, Lingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799887/
https://www.ncbi.nlm.nih.gov/pubmed/35127383
http://dx.doi.org/10.1016/j.apsb.2021.06.008

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