ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity

Formation of cytoplasmic RNA-protein structures called stress granules (SGs) is a highly conserved cellular response to stress. Abnormal metabolism of SGs may contribute to the pathogenesis of (neuro)degenerative diseases such as amyotrophic lateral sclerosis (ALS). Many SG proteins are affected by...

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Detalles Bibliográficos
Autores principales: An, Haiyan, Litscher, Gioana, Watanabe, Naruaki, Wei, Wenbin, Hashimoto, Tadafumi, Iwatsubo, Takeshi, Buchman, Vladimir L., Shelkovnikova, Tatyana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799889/
https://www.ncbi.nlm.nih.gov/pubmed/34915152
http://dx.doi.org/10.1016/j.nbd.2021.105585

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