SK-Channel Activation Alters Peripheral Metabolic Pathways in Mice, but Not Lipopolysaccharide-Induced Fever or Inflammation

PURPOSE: Previously, we have shown that CyPPA (cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine), a pharmacological small-conductance calcium-activated potassium (SK)–channel positive modulator, antagonizes lipopolysaccharide (LPS)-induced cytokine expression in microglial ce...

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Detalles Bibliográficos
Autores principales: Bredehöft, Janne, Dolga, Amalia M, Honrath, Birgit, Wache, Sybille, Mazurek, Sybille, Culmsee, Carsten, Schoemaker, Regien G, Gerstberger, Rüdiger, Roth, Joachim, Rummel, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800008/
https://www.ncbi.nlm.nih.gov/pubmed/35115803
http://dx.doi.org/10.2147/JIR.S338812

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