miR-376a-3p and miR-376b-3p overexpression in Hutchinson-Gilford progeria fibroblasts inhibits cell proliferation and induces premature senescence

Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder, in which an abnormal and toxic protein called progerin, accumulates in cell nuclei, leading to major cellular defects. Among them, chromatin remodeling drives gene expression changes, including miRNA dysregulation. In our study,...

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Detalles Bibliográficos
Autores principales: Frankel, Diane, Delecourt, Valérie, Novoa-del-Toro, Elva-María, Robin, Jérôme D., Airault, Coraline, Bartoli, Catherine, Carabalona, Aurélie, Perrin, Sophie, Mazaleyrat, Kilian, De Sandre-Giovannoli, Annachiara, Magdinier, Frederique, Baudot, Anaïs, Lévy, Nicolas, Kaspi, Elise, Roll, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800101/
https://www.ncbi.nlm.nih.gov/pubmed/35118365
http://dx.doi.org/10.1016/j.isci.2022.103757

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