Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life

Monoclonal IgG antibodies are the fastest growing class of biologics, but large differences exist in their plasma half-life in humans. Thus, to design IgG antibodies with favorable pharmacokinetics, it is crucial to identify the determinants of such differences. Here, we demonstrate that the variabl...

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Detalles Bibliográficos
Autores principales: Grevys, Algirdas, Frick, Rahel, Mester, Simone, Flem-Karlsen, Karine, Nilsen, Jeannette, Foss, Stian, Sand, Kine Marita Knudsen, Emrich, Thomas, Fischer, Jens Andre Alexander, Greiff, Victor, Sandlie, Inger, Schlothauer, Tilman, Andersen, Jan Terje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800109/
https://www.ncbi.nlm.nih.gov/pubmed/35118359
http://dx.doi.org/10.1016/j.isci.2022.103746

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