The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase

Cancer is often characterized by aberrant gene expression patterns caused by the inappropriate activation of transcription factors. Signal transducer and activator of transcription 3 (STAT3) is a key transcriptional regulator of many protumorigenic processes and is persistently activated in many typ...

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Detalles Bibliográficos
Autores principales: Heppler, Lisa N., Attarha, Sanaz, Persaud, Rosanne, Brown, Jennifer I., Wang, Peng, Petrova, Boryana, Tošić, Isidora, Burton, Foster B., Flamand, Yael, Walker, Sarah R., Yeh, Jennifer E., Zubarev, Roman A., Gaetani, Massimiliano, Kanarek, Naama, Page, Brent D.G., Frank, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800111/
https://www.ncbi.nlm.nih.gov/pubmed/34953855
http://dx.doi.org/10.1016/j.jbc.2021.101531

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