The ASCC2 CUE domain in the ALKBH3–ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin

Alkylation of DNA and RNA is a potentially toxic lesion that can result in mutations and even cell death. In response to alkylation damage, K63-linked polyubiquitin chains are assembled that localize the Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3–Activating Signal Cointegrator 1 Comple...

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Detalles Bibliográficos
Autores principales: Lombardi, Patrick M., Haile, Sara, Rusanov, Timur, Rodell, Rebecca, Anoh, Rita, Baer, Julia G., Burke, Kate A., Gray, Lauren N., Hacker, Abigail R., Kebreau, Kayla R., Ngandu, Christine K., Orland, Hannah A., Osei-Asante, Emmanuella, Schmelyun, Dhane P., Shorb, Devin E., Syed, Shaheer H., Veilleux, Julianna M., Majumdar, Ananya, Mosammaparast, Nima, Wolberger, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800115/
https://www.ncbi.nlm.nih.gov/pubmed/34971705
http://dx.doi.org/10.1016/j.jbc.2021.101545

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