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Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose

G6PC2 encodes a glucose-6-phosphatase (G6Pase) catalytic subunit that modulates the sensitivity of insulin secretion to glucose and thereby regulates fasting blood glucose (FBG). A common single-nucleotide polymorphism (SNP) in G6PC2, rs560887 is an important determinant of human FBG variability. Th...

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Detalles Bibliográficos
Autores principales:	Overway, Emily M., Bosma, Karin J., Claxton, Derek P., Oeser, James K., Singh, Kritika, Breidenbach, Lindsay B., Mchaourab, Hassane S., Davis, Lea K., O'Brien, Richard M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800118/ https://www.ncbi.nlm.nih.gov/pubmed/34954144 http://dx.doi.org/10.1016/j.jbc.2021.101534

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