High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes upon phosphate binding

The mitochondrial enzyme glutaminase C (GAC) is upregulated in many cancer cells to catalyze the first step in glutamine metabolism, the hydrolysis of glutamine to glutamate. The dependence of cancer cells on this transformed metabolic pathway highlights GAC as a potentially important therapeutic ta...

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Detalles Bibliográficos
Autores principales: Nguyen, Thuy-Tien T., Ramachandran, Sekar, Hill, Matthew J., Cerione, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800119/
https://www.ncbi.nlm.nih.gov/pubmed/34999118
http://dx.doi.org/10.1016/j.jbc.2022.101564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800119/
https://www.ncbi.nlm.nih.gov/pubmed/34999118
http://dx.doi.org/10.1016/j.jbc.2022.101564

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