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High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes upon phosphate binding
The mitochondrial enzyme glutaminase C (GAC) is upregulated in many cancer cells to catalyze the first step in glutamine metabolism, the hydrolysis of glutamine to glutamate. The dependence of cancer cells on this transformed metabolic pathway highlights GAC as a potentially important therapeutic ta...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800119/ https://www.ncbi.nlm.nih.gov/pubmed/34999118 http://dx.doi.org/10.1016/j.jbc.2022.101564 |