The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and glutathione

Viral spike proteins play important roles in the viral entry process, facilitating attachment to cellular receptors and fusion of the viral envelope with the cell membrane. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein binds to the cellular receptor angiotensin convertin...

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Detalles Bibliográficos
Autores principales: Murae, Mana, Shimizu, Yoshimi, Yamamoto, Yuichiro, Kobayashi, Asuka, Houri, Masumi, Inoue, Tetsuya, Irie, Takuya, Gemba, Ryutaro, Kondo, Yosuke, Nakano, Yoshio, Miyazaki, Satoru, Yamada, Daisuke, Saitoh, Akiyoshi, Ishii, Isao, Onodera, Taishi, Takahashi, Yoshimasa, Wakita, Takaji, Fukasawa, Masayoshi, Noguchi, Kohji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800159/
https://www.ncbi.nlm.nih.gov/pubmed/35123263
http://dx.doi.org/10.1016/j.bbrc.2022.01.106

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