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Association of body mass index with COVID-19 related in-hospital death()

BACKGROUND: Patients with extreme body mass indices (BMI) could have an increased risk of death while hospitalized for COVID-19. METHODS: The database of the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) was used to assess the time to in-hospital death with compet...

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Autores principales: Bouziotis, Jason, Arvanitakis, Marianna, Preiser, Jean-Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800162/
https://www.ncbi.nlm.nih.gov/pubmed/35123821
http://dx.doi.org/10.1016/j.clnu.2022.01.017
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author Bouziotis, Jason
Arvanitakis, Marianna
Preiser, Jean-Charles
author_facet Bouziotis, Jason
Arvanitakis, Marianna
Preiser, Jean-Charles
author_sort Bouziotis, Jason
collection PubMed
description BACKGROUND: Patients with extreme body mass indices (BMI) could have an increased risk of death while hospitalized for COVID-19. METHODS: The database of the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) was used to assess the time to in-hospital death with competing-risks regression by sex and between the categories of BMI. RESULTS: Data from 12,137 patients (age 60.0 ± 16.2 years, 59% males, BMI 29.4 ± 6.9 kg/m(2)) of 48 countries were available. By univariate analysis, underweight patients had a higher risk of mortality than the other patients (sub-hazard ratio (SHR) 1.75 [1.44–2.14]). Mortality was lower in normal (SHR 0.69 [0.58–0.85]), overweight (SHR 0.53 [0.43–0.65]) and obese (SHR 0.55 [0.44–0.67]) than in underweight patients. Multivariable analysis (adjusted for age, chronic pulmonary disease, malignant neoplasia, type 2 diabetes) confirmed that in-hospital mortality of underweight patients was higher than overweight patients (females: SHR 0.63 [0.45–0.88] and males: 0.69 [0.51–0.94]). CONCLUSION: Even though these findings do not imply changes in the medical care of hospitalized patients, they support the use of BMI category for the stratification of patients enrolled in interventional studies where mortality is recorded as an outcome.
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spelling pubmed-88001622022-01-31 Association of body mass index with COVID-19 related in-hospital death() Bouziotis, Jason Arvanitakis, Marianna Preiser, Jean-Charles Clin Nutr Covid-19 BACKGROUND: Patients with extreme body mass indices (BMI) could have an increased risk of death while hospitalized for COVID-19. METHODS: The database of the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) was used to assess the time to in-hospital death with competing-risks regression by sex and between the categories of BMI. RESULTS: Data from 12,137 patients (age 60.0 ± 16.2 years, 59% males, BMI 29.4 ± 6.9 kg/m(2)) of 48 countries were available. By univariate analysis, underweight patients had a higher risk of mortality than the other patients (sub-hazard ratio (SHR) 1.75 [1.44–2.14]). Mortality was lower in normal (SHR 0.69 [0.58–0.85]), overweight (SHR 0.53 [0.43–0.65]) and obese (SHR 0.55 [0.44–0.67]) than in underweight patients. Multivariable analysis (adjusted for age, chronic pulmonary disease, malignant neoplasia, type 2 diabetes) confirmed that in-hospital mortality of underweight patients was higher than overweight patients (females: SHR 0.63 [0.45–0.88] and males: 0.69 [0.51–0.94]). CONCLUSION: Even though these findings do not imply changes in the medical care of hospitalized patients, they support the use of BMI category for the stratification of patients enrolled in interventional studies where mortality is recorded as an outcome. The Authors. Published by Elsevier Ltd. 2022-12 2022-01-29 /pmc/articles/PMC8800162/ /pubmed/35123821 http://dx.doi.org/10.1016/j.clnu.2022.01.017 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Covid-19
Bouziotis, Jason
Arvanitakis, Marianna
Preiser, Jean-Charles
Association of body mass index with COVID-19 related in-hospital death()
title Association of body mass index with COVID-19 related in-hospital death()
title_full Association of body mass index with COVID-19 related in-hospital death()
title_fullStr Association of body mass index with COVID-19 related in-hospital death()
title_full_unstemmed Association of body mass index with COVID-19 related in-hospital death()
title_short Association of body mass index with COVID-19 related in-hospital death()
title_sort association of body mass index with covid-19 related in-hospital death()
topic Covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800162/
https://www.ncbi.nlm.nih.gov/pubmed/35123821
http://dx.doi.org/10.1016/j.clnu.2022.01.017
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