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Exophiala dermatitidis, ‘the real black fungus’ fungemia in a patient with COVID-19

The second wave of the COVID-19 pandemic in India had brought with it a surge of ‘black fungus’ co-infection, which is a misnomer for mucormycosis. The present case illustrates the ‘real black fungus’ infection in a 50-year old male patient with COVID-19 pneumonia, who otherwise had no significant p...

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Autores principales: Tzar, Mohd Nizam, Meor Jamaludin, Wan Husna Barakah, Abdul Wahab, Asrul, Ding, Chuan Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800164/
https://www.ncbi.nlm.nih.gov/pubmed/35127454
http://dx.doi.org/10.1016/j.idcr.2022.e01428
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author Tzar, Mohd Nizam
Meor Jamaludin, Wan Husna Barakah
Abdul Wahab, Asrul
Ding, Chuan Hun
author_facet Tzar, Mohd Nizam
Meor Jamaludin, Wan Husna Barakah
Abdul Wahab, Asrul
Ding, Chuan Hun
author_sort Tzar, Mohd Nizam
collection PubMed
description The second wave of the COVID-19 pandemic in India had brought with it a surge of ‘black fungus’ co-infection, which is a misnomer for mucormycosis. The present case illustrates the ‘real black fungus’ infection in a 50-year old male patient with COVID-19 pneumonia, who otherwise had no significant previous medical history. He was admitted on day 8 of COVID-19 illness and was intubated due to persistently low oxygen saturation. Blood cultures were positive for flask-shaped dematiaceous budding yeasts with pseudohyphae formation, which grew as brown-black fuzzy colonies on Sabouraud dextrose agar. The isolate was identified as Exophiala dermatitidis based on phenotypic characterization. Despite antifungal therapy with amphotericin B and itraconazole, the patient deteriorated rapidly and succumbed to acute respiratory distress syndrome and multiorgan failure. A review of reported cases of Exophiala dermatitidis fungemia over the last 5-years is discussed.
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spelling pubmed-88001642022-01-31 Exophiala dermatitidis, ‘the real black fungus’ fungemia in a patient with COVID-19 Tzar, Mohd Nizam Meor Jamaludin, Wan Husna Barakah Abdul Wahab, Asrul Ding, Chuan Hun IDCases Case Report The second wave of the COVID-19 pandemic in India had brought with it a surge of ‘black fungus’ co-infection, which is a misnomer for mucormycosis. The present case illustrates the ‘real black fungus’ infection in a 50-year old male patient with COVID-19 pneumonia, who otherwise had no significant previous medical history. He was admitted on day 8 of COVID-19 illness and was intubated due to persistently low oxygen saturation. Blood cultures were positive for flask-shaped dematiaceous budding yeasts with pseudohyphae formation, which grew as brown-black fuzzy colonies on Sabouraud dextrose agar. The isolate was identified as Exophiala dermatitidis based on phenotypic characterization. Despite antifungal therapy with amphotericin B and itraconazole, the patient deteriorated rapidly and succumbed to acute respiratory distress syndrome and multiorgan failure. A review of reported cases of Exophiala dermatitidis fungemia over the last 5-years is discussed. Elsevier 2022-01-29 /pmc/articles/PMC8800164/ /pubmed/35127454 http://dx.doi.org/10.1016/j.idcr.2022.e01428 Text en © 2022 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tzar, Mohd Nizam
Meor Jamaludin, Wan Husna Barakah
Abdul Wahab, Asrul
Ding, Chuan Hun
Exophiala dermatitidis, ‘the real black fungus’ fungemia in a patient with COVID-19
title Exophiala dermatitidis, ‘the real black fungus’ fungemia in a patient with COVID-19
title_full Exophiala dermatitidis, ‘the real black fungus’ fungemia in a patient with COVID-19
title_fullStr Exophiala dermatitidis, ‘the real black fungus’ fungemia in a patient with COVID-19
title_full_unstemmed Exophiala dermatitidis, ‘the real black fungus’ fungemia in a patient with COVID-19
title_short Exophiala dermatitidis, ‘the real black fungus’ fungemia in a patient with COVID-19
title_sort exophiala dermatitidis, ‘the real black fungus’ fungemia in a patient with covid-19
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800164/
https://www.ncbi.nlm.nih.gov/pubmed/35127454
http://dx.doi.org/10.1016/j.idcr.2022.e01428
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