Mendelian randomization highlights significant difference and genetic heterogeneity in clinically diagnosed Alzheimer’s disease GWAS and self-report proxy phenotype GWAX

BACKGROUND: Until now, Mendelian randomization (MR) studies have investigated the causal association of risk factors with Alzheimer’s disease (AD) using large-scale AD genome-wide association studies (GWAS), GWAS by proxy (GWAX), and meta-analyses of GWAS and GWAX (GWAS+GWAX) datasets. However, it c...

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Detalles Bibliográficos
Autores principales: Liu, Haijie, Hu, Yang, Zhang, Yan, Zhang, Haihua, Gao, Shan, Wang, Longcai, Wang, Tao, Han, Zhifa, Sun, Bao-liang, Liu, Guiyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800228/
https://www.ncbi.nlm.nih.gov/pubmed/35090530
http://dx.doi.org/10.1186/s13195-022-00963-3

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