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Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine

Stem cells transplantation is the main method of tissue engineering regeneration treatment, the viability and therapeutic efficiency are limited. Scaffold materials also play an important role in tissue engineering, whereas there are still many limitations, such as rejection and toxic side effects c...

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Autores principales: Chen, Yuanting, Huang, Huacong, Li, Gaoxing, Yu, Jianyu, Fang, Fuchun, Qiu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800229/
https://www.ncbi.nlm.nih.gov/pubmed/35093155
http://dx.doi.org/10.1186/s13287-022-02716-3
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author Chen, Yuanting
Huang, Huacong
Li, Gaoxing
Yu, Jianyu
Fang, Fuchun
Qiu, Wei
author_facet Chen, Yuanting
Huang, Huacong
Li, Gaoxing
Yu, Jianyu
Fang, Fuchun
Qiu, Wei
author_sort Chen, Yuanting
collection PubMed
description Stem cells transplantation is the main method of tissue engineering regeneration treatment, the viability and therapeutic efficiency are limited. Scaffold materials also play an important role in tissue engineering, whereas there are still many limitations, such as rejection and toxic side effects caused by scaffold materials. Cell sheet engineering is a scaffold-free tissue technology, which avoids the side effects of traditional scaffolds and maximizes the function of stem cells. It is increasingly being used in the field of tissue regenerative medicine. Dental-derived mesenchymal stem cells (DMSCs) are multipotent cells that exist in various dental tissues and can be used in stem cell-based therapy, which is impactful in regenerative medicine. Emerging evidences show that cell sheets derived from DMSCs have better effects in the field of regenerative medicine applications. Extracellular matrix (ECM) is the main component of cell sheets, which is a dynamic repository of signalling biological molecules and has a variety of biological functions and may play an important role in the application of cell sheets. In this review, we summarized the application status, mechanisms that sheets and ECM may play and future prospect of DMSC sheets on regeneration medicine.
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spelling pubmed-88002292022-02-02 Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine Chen, Yuanting Huang, Huacong Li, Gaoxing Yu, Jianyu Fang, Fuchun Qiu, Wei Stem Cell Res Ther Review Stem cells transplantation is the main method of tissue engineering regeneration treatment, the viability and therapeutic efficiency are limited. Scaffold materials also play an important role in tissue engineering, whereas there are still many limitations, such as rejection and toxic side effects caused by scaffold materials. Cell sheet engineering is a scaffold-free tissue technology, which avoids the side effects of traditional scaffolds and maximizes the function of stem cells. It is increasingly being used in the field of tissue regenerative medicine. Dental-derived mesenchymal stem cells (DMSCs) are multipotent cells that exist in various dental tissues and can be used in stem cell-based therapy, which is impactful in regenerative medicine. Emerging evidences show that cell sheets derived from DMSCs have better effects in the field of regenerative medicine applications. Extracellular matrix (ECM) is the main component of cell sheets, which is a dynamic repository of signalling biological molecules and has a variety of biological functions and may play an important role in the application of cell sheets. In this review, we summarized the application status, mechanisms that sheets and ECM may play and future prospect of DMSC sheets on regeneration medicine. BioMed Central 2022-01-29 /pmc/articles/PMC8800229/ /pubmed/35093155 http://dx.doi.org/10.1186/s13287-022-02716-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chen, Yuanting
Huang, Huacong
Li, Gaoxing
Yu, Jianyu
Fang, Fuchun
Qiu, Wei
Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine
title Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine
title_full Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine
title_fullStr Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine
title_full_unstemmed Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine
title_short Dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine
title_sort dental-derived mesenchymal stem cell sheets: a prospective tissue engineering for regenerative medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800229/
https://www.ncbi.nlm.nih.gov/pubmed/35093155
http://dx.doi.org/10.1186/s13287-022-02716-3
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