Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer’s disease

BACKGROUND: The pathologic accumulation and aggregation of tau is a hallmark of tauopathies including Alzheimer’s disease (AD). However, the molecular mechanisms mediating tau aggregation in AD remain elusive. The incidence of AD is increased in patients with type 2 diabetes (T2DM), which is charact...

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Detalles Bibliográficos
Autores principales: Zhang, Guoxin, Meng, Lanxia, Wang, Zhihao, Peng, Qinyu, Chen, Guiqin, Xiong, Jing, Zhang, Zhentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800231/
https://www.ncbi.nlm.nih.gov/pubmed/35093145
http://dx.doi.org/10.1186/s13024-022-00518-y

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