Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT(2B)R/β-arrestin2 pathway

BACKGROUND: Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to directly bind with 5-HT(2B) receptor (5-HT(2B)R), but the precise mechanisms, whereby fluoxetine confers the anti-depressive actions via 5-HT(2B)R is not fully understood. Although neuroinflammation-induced A1 ast...

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Detalles Bibliográficos
Autores principales: Fang, Yinquan, Ding, Xiao, Zhang, Yihe, Cai, Lei, Ge, Yuan, Ma, Kaiyang, Xu, Rong, Li, Shanshan, Song, Mengmeng, Zhu, Hong, Liu, Jiaqi, Ding, Jianhua, Lu, Ming, Hu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800238/
https://www.ncbi.nlm.nih.gov/pubmed/35093099
http://dx.doi.org/10.1186/s12974-022-02389-y

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