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AMPK-autophagy-mediated inhibition of microRNA-30a-5p alleviates morphine tolerance via SOCS3-dependent neuroinflammation suppression

BACKGROUND: The development of morphine tolerance is a clinical challenge for managing severe pain. Studies have shown that neuroinflammation is a critical aspect for the development of analgesic tolerance. We found that AMPK-autophagy activation could suppress neuroinflammation and improve morphine...

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Detalles Bibliográficos
Autores principales:	Wan, Li, Jia, Ru-Meng, Ji, Lu-Lu, Qin, Xin-Miao, Hu, Liang, Hu, Fan, Han, Yuan, Pan, Yin-Bing, Jiang, Chun-Yi, Liu, Wen-Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800317/ https://www.ncbi.nlm.nih.gov/pubmed/35093117 http://dx.doi.org/10.1186/s12974-022-02384-3

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