Progress of HOTAIR-microRNA in hepatocellular carcinoma

The Hox transcript antisense intergenic RNA (HOTAIR) has been identified as a tumor gene, and its expression in HCC is significantly increased. HOTAIR is associated with the proliferation, invasion, metastasis and poor prognosis of HCC. In addition, HOTAIR can also regulate the expression and functi...

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Autores principales: Wang, Bing-rong, Chu, Dong-xia, Cheng, Mei-yu, Jin, Yu, Luo, Hao-ge, Li, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800341/
https://www.ncbi.nlm.nih.gov/pubmed/35093153
http://dx.doi.org/10.1186/s13053-022-00210-8
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author Wang, Bing-rong
Chu, Dong-xia
Cheng, Mei-yu
Jin, Yu
Luo, Hao-ge
Li, Na
author_facet Wang, Bing-rong
Chu, Dong-xia
Cheng, Mei-yu
Jin, Yu
Luo, Hao-ge
Li, Na
author_sort Wang, Bing-rong
collection PubMed
description The Hox transcript antisense intergenic RNA (HOTAIR) has been identified as a tumor gene, and its expression in HCC is significantly increased. HOTAIR is associated with the proliferation, invasion, metastasis and poor prognosis of HCC. In addition, HOTAIR can also regulate the expression and function of microRNA by recruiting the polycomb repressive complex 2 (PRC2) and competitive adsorption, thus promoting the occurrence and development of HCC. In this review, we discussed the two mechanisms of HOTAIR regulating miRNA through direct binding miRNA and indirect regulation, and emphasized the role of HOTAIR in HCC through miRNA, explained the regulatory pathway of HOTAIR-miRNA-mRNA and introduced the role of this pathway in HCC proliferation, drug resistance, invasion and metastasis.
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spelling pubmed-88003412022-02-02 Progress of HOTAIR-microRNA in hepatocellular carcinoma Wang, Bing-rong Chu, Dong-xia Cheng, Mei-yu Jin, Yu Luo, Hao-ge Li, Na Hered Cancer Clin Pract Review The Hox transcript antisense intergenic RNA (HOTAIR) has been identified as a tumor gene, and its expression in HCC is significantly increased. HOTAIR is associated with the proliferation, invasion, metastasis and poor prognosis of HCC. In addition, HOTAIR can also regulate the expression and function of microRNA by recruiting the polycomb repressive complex 2 (PRC2) and competitive adsorption, thus promoting the occurrence and development of HCC. In this review, we discussed the two mechanisms of HOTAIR regulating miRNA through direct binding miRNA and indirect regulation, and emphasized the role of HOTAIR in HCC through miRNA, explained the regulatory pathway of HOTAIR-miRNA-mRNA and introduced the role of this pathway in HCC proliferation, drug resistance, invasion and metastasis. BioMed Central 2022-01-29 /pmc/articles/PMC8800341/ /pubmed/35093153 http://dx.doi.org/10.1186/s13053-022-00210-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Bing-rong
Chu, Dong-xia
Cheng, Mei-yu
Jin, Yu
Luo, Hao-ge
Li, Na
Progress of HOTAIR-microRNA in hepatocellular carcinoma
title Progress of HOTAIR-microRNA in hepatocellular carcinoma
title_full Progress of HOTAIR-microRNA in hepatocellular carcinoma
title_fullStr Progress of HOTAIR-microRNA in hepatocellular carcinoma
title_full_unstemmed Progress of HOTAIR-microRNA in hepatocellular carcinoma
title_short Progress of HOTAIR-microRNA in hepatocellular carcinoma
title_sort progress of hotair-microrna in hepatocellular carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800341/
https://www.ncbi.nlm.nih.gov/pubmed/35093153
http://dx.doi.org/10.1186/s13053-022-00210-8
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