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Recurrent Drug-Induced Hypersensitivity Syndrome Following Bortezomib for Multiple Myeloma
Drug-induced hypersensitivity syndrome is a rare, severe, and delayed hypersensitivity reaction that may occur with exposure to a number of medications. Typical implicated medications include aromatic anticonvulsants, sulfonamides, minocycline, dapsone, and allopurinol. Bortezomib is a proteasome in...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800392/ https://www.ncbi.nlm.nih.gov/pubmed/35141083 http://dx.doi.org/10.7759/cureus.20830 |
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author | Ambur, Austin B Nathoo, Rajiv |
author_facet | Ambur, Austin B Nathoo, Rajiv |
author_sort | Ambur, Austin B |
collection | PubMed |
description | Drug-induced hypersensitivity syndrome is a rare, severe, and delayed hypersensitivity reaction that may occur with exposure to a number of medications. Typical implicated medications include aromatic anticonvulsants, sulfonamides, minocycline, dapsone, and allopurinol. Bortezomib is a proteasome inhibitor and has rarely been associated with cutaneous hypersensitivity reactions. We report a case of recurrent drug-induced hypersensitivity syndrome secondary to bortezomib in a patient with multiple myeloma. The aim of this article is to highlight a unique mediation that may cause drug-induced hypersensitivity syndrome and to emphasize the challenge of managing these patients long-term to prevent relapse of the syndrome. |
format | Online Article Text |
id | pubmed-8800392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-88003922022-02-08 Recurrent Drug-Induced Hypersensitivity Syndrome Following Bortezomib for Multiple Myeloma Ambur, Austin B Nathoo, Rajiv Cureus Dermatology Drug-induced hypersensitivity syndrome is a rare, severe, and delayed hypersensitivity reaction that may occur with exposure to a number of medications. Typical implicated medications include aromatic anticonvulsants, sulfonamides, minocycline, dapsone, and allopurinol. Bortezomib is a proteasome inhibitor and has rarely been associated with cutaneous hypersensitivity reactions. We report a case of recurrent drug-induced hypersensitivity syndrome secondary to bortezomib in a patient with multiple myeloma. The aim of this article is to highlight a unique mediation that may cause drug-induced hypersensitivity syndrome and to emphasize the challenge of managing these patients long-term to prevent relapse of the syndrome. Cureus 2021-12-30 /pmc/articles/PMC8800392/ /pubmed/35141083 http://dx.doi.org/10.7759/cureus.20830 Text en Copyright © 2021, Ambur et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Dermatology Ambur, Austin B Nathoo, Rajiv Recurrent Drug-Induced Hypersensitivity Syndrome Following Bortezomib for Multiple Myeloma |
title | Recurrent Drug-Induced Hypersensitivity Syndrome Following Bortezomib for Multiple Myeloma |
title_full | Recurrent Drug-Induced Hypersensitivity Syndrome Following Bortezomib for Multiple Myeloma |
title_fullStr | Recurrent Drug-Induced Hypersensitivity Syndrome Following Bortezomib for Multiple Myeloma |
title_full_unstemmed | Recurrent Drug-Induced Hypersensitivity Syndrome Following Bortezomib for Multiple Myeloma |
title_short | Recurrent Drug-Induced Hypersensitivity Syndrome Following Bortezomib for Multiple Myeloma |
title_sort | recurrent drug-induced hypersensitivity syndrome following bortezomib for multiple myeloma |
topic | Dermatology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800392/ https://www.ncbi.nlm.nih.gov/pubmed/35141083 http://dx.doi.org/10.7759/cureus.20830 |
work_keys_str_mv | AT amburaustinb recurrentdruginducedhypersensitivitysyndromefollowingbortezomibformultiplemyeloma AT nathoorajiv recurrentdruginducedhypersensitivitysyndromefollowingbortezomibformultiplemyeloma |