Pathological effects of SARS-CoV-2 on hematological and immunological cells: Alterations in count, morphology, and function

The novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 outbreak, spread rapidly and infected more than 140 million people with more than three million victims worldwide. The SARS-CoV-2 causes destructive changes in the immunological and hematological...

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Autores principales: Ahmadi, Ehsan, Bagherpour, Zahra, Zarei, Elmira, Omidkhoda, Azadeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier GmbH. 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800420/
https://www.ncbi.nlm.nih.gov/pubmed/35121363
http://dx.doi.org/10.1016/j.prp.2022.153782
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author Ahmadi, Ehsan
Bagherpour, Zahra
Zarei, Elmira
Omidkhoda, Azadeh
author_facet Ahmadi, Ehsan
Bagherpour, Zahra
Zarei, Elmira
Omidkhoda, Azadeh
author_sort Ahmadi, Ehsan
collection PubMed
description The novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 outbreak, spread rapidly and infected more than 140 million people with more than three million victims worldwide. The SARS-CoV-2 causes destructive changes in the immunological and hematological system of the host. These alterations appear to play a critical role in disease pathology and the emerging of clinical manifestations. In this review, we aimed to discuss the effect of COVID-19 on the count, function and morphology of immune and blood cells and the role of these changes in the pathophysiology of the disease. Knowledge of these changes may help with better management and treatment of COVID-19 patients.
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spelling pubmed-88004202022-01-31 Pathological effects of SARS-CoV-2 on hematological and immunological cells: Alterations in count, morphology, and function Ahmadi, Ehsan Bagherpour, Zahra Zarei, Elmira Omidkhoda, Azadeh Pathol Res Pract Review The novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 outbreak, spread rapidly and infected more than 140 million people with more than three million victims worldwide. The SARS-CoV-2 causes destructive changes in the immunological and hematological system of the host. These alterations appear to play a critical role in disease pathology and the emerging of clinical manifestations. In this review, we aimed to discuss the effect of COVID-19 on the count, function and morphology of immune and blood cells and the role of these changes in the pathophysiology of the disease. Knowledge of these changes may help with better management and treatment of COVID-19 patients. Elsevier GmbH. 2022-03 2022-01-29 /pmc/articles/PMC8800420/ /pubmed/35121363 http://dx.doi.org/10.1016/j.prp.2022.153782 Text en © 2022 Elsevier GmbH. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Ahmadi, Ehsan
Bagherpour, Zahra
Zarei, Elmira
Omidkhoda, Azadeh
Pathological effects of SARS-CoV-2 on hematological and immunological cells: Alterations in count, morphology, and function
title Pathological effects of SARS-CoV-2 on hematological and immunological cells: Alterations in count, morphology, and function
title_full Pathological effects of SARS-CoV-2 on hematological and immunological cells: Alterations in count, morphology, and function
title_fullStr Pathological effects of SARS-CoV-2 on hematological and immunological cells: Alterations in count, morphology, and function
title_full_unstemmed Pathological effects of SARS-CoV-2 on hematological and immunological cells: Alterations in count, morphology, and function
title_short Pathological effects of SARS-CoV-2 on hematological and immunological cells: Alterations in count, morphology, and function
title_sort pathological effects of sars-cov-2 on hematological and immunological cells: alterations in count, morphology, and function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800420/
https://www.ncbi.nlm.nih.gov/pubmed/35121363
http://dx.doi.org/10.1016/j.prp.2022.153782
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