SARS-CoV-2 Placental Infection in an Unvaccinated Mother Resulting in Fetal Demise

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy may have devastating complications including fetal demise. Here, we describe a case of SARS-CoV-2 infection in a second-trimester pregnancy. The placenta demonstrated the presence of SARS-CoV-2 viral RNA along with i...

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Detalles Bibliográficos
Autores principales: Bewley, Dominic J, Lee, Jessica, Popescu, Oana, Oviedo, Angelica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Obstetrics/Gynecology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800441/
https://www.ncbi.nlm.nih.gov/pubmed/35141086
http://dx.doi.org/10.7759/cureus.20833
Descripción
Sumario:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy may have devastating complications including fetal demise. Here, we describe a case of SARS-CoV-2 infection in a second-trimester pregnancy. The placenta demonstrated the presence of SARS-CoV-2 viral RNA along with intervillositis and perivillous fibrin deposition. SARS-CoV-2 directly infects the trophoblastic cells of the placenta through the angiotensin-converting enzyme 2 receptor. This case report details the clinical history of a SARS-CoV-2-infected pregnancy with fetal demise. In addition, we show the images of the placental pathology and SARS-CoV-2 RNA in situ studies.

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