SARS-CoV-2 Placental Infection in an Unvaccinated Mother Resulting in Fetal Demise

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy may have devastating complications including fetal demise. Here, we describe a case of SARS-CoV-2 infection in a second-trimester pregnancy. The placenta demonstrated the presence of SARS-CoV-2 viral RNA along with i...

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Detalles Bibliográficos
Autores principales: Bewley, Dominic J, Lee, Jessica, Popescu, Oana, Oviedo, Angelica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Obstetrics/Gynecology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800441/
https://www.ncbi.nlm.nih.gov/pubmed/35141086
http://dx.doi.org/10.7759/cureus.20833
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author Bewley, Dominic J
Lee, Jessica
Popescu, Oana
Oviedo, Angelica
author_facet Bewley, Dominic J
Lee, Jessica
Popescu, Oana
Oviedo, Angelica
author_sort Bewley, Dominic J
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy may have devastating complications including fetal demise. Here, we describe a case of SARS-CoV-2 infection in a second-trimester pregnancy. The placenta demonstrated the presence of SARS-CoV-2 viral RNA along with intervillositis and perivillous fibrin deposition. SARS-CoV-2 directly infects the trophoblastic cells of the placenta through the angiotensin-converting enzyme 2 receptor. This case report details the clinical history of a SARS-CoV-2-infected pregnancy with fetal demise. In addition, we show the images of the placental pathology and SARS-CoV-2 RNA in situ studies.
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spelling pubmed-88004412022-02-08 SARS-CoV-2 Placental Infection in an Unvaccinated Mother Resulting in Fetal Demise Bewley, Dominic J Lee, Jessica Popescu, Oana Oviedo, Angelica Cureus Obstetrics/Gynecology Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy may have devastating complications including fetal demise. Here, we describe a case of SARS-CoV-2 infection in a second-trimester pregnancy. The placenta demonstrated the presence of SARS-CoV-2 viral RNA along with intervillositis and perivillous fibrin deposition. SARS-CoV-2 directly infects the trophoblastic cells of the placenta through the angiotensin-converting enzyme 2 receptor. This case report details the clinical history of a SARS-CoV-2-infected pregnancy with fetal demise. In addition, we show the images of the placental pathology and SARS-CoV-2 RNA in situ studies. Cureus 2021-12-30 /pmc/articles/PMC8800441/ /pubmed/35141086 http://dx.doi.org/10.7759/cureus.20833 Text en Copyright © 2021, Bewley et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Obstetrics/Gynecology
Bewley, Dominic J
Lee, Jessica
Popescu, Oana
Oviedo, Angelica
SARS-CoV-2 Placental Infection in an Unvaccinated Mother Resulting in Fetal Demise
title SARS-CoV-2 Placental Infection in an Unvaccinated Mother Resulting in Fetal Demise
title_full SARS-CoV-2 Placental Infection in an Unvaccinated Mother Resulting in Fetal Demise
title_fullStr SARS-CoV-2 Placental Infection in an Unvaccinated Mother Resulting in Fetal Demise
title_full_unstemmed SARS-CoV-2 Placental Infection in an Unvaccinated Mother Resulting in Fetal Demise
title_short SARS-CoV-2 Placental Infection in an Unvaccinated Mother Resulting in Fetal Demise
title_sort sars-cov-2 placental infection in an unvaccinated mother resulting in fetal demise
topic Obstetrics/Gynecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800441/
https://www.ncbi.nlm.nih.gov/pubmed/35141086
http://dx.doi.org/10.7759/cureus.20833
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AT oviedoangelica sarscov2placentalinfectioninanunvaccinatedmotherresultinginfetaldemise

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