Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review

The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine-protein kinase that senses and combines various environmental signals to regulate the growth and homeostasis of human cells. This signaling pathway synchronizes many critical cellular processes and is involved i...

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Autores principales: Yarahmadi, Amir, Azarpira, Negar, Mostafavi-Pour, Zohreh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2021
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800458/
https://www.ncbi.nlm.nih.gov/pubmed/35178356
http://dx.doi.org/10.22088/IJMCM.BUMS.10.3.181
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author Yarahmadi, Amir
Azarpira, Negar
Mostafavi-Pour, Zohreh
author_facet Yarahmadi, Amir
Azarpira, Negar
Mostafavi-Pour, Zohreh
author_sort Yarahmadi, Amir
collection PubMed
description The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine-protein kinase that senses and combines various environmental signals to regulate the growth and homeostasis of human cells. This signaling pathway synchronizes many critical cellular processes and is involved in an increasing number of pathological conditions such as diabetes, cancer, obesity, and metabolic syndrome. Here, we review different complications of diabetes that are associated with mTOR complex 1 imbalance. We further discuss pharmacological approaches to treat diabetes complications linked to mTOR deregulation.
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spelling pubmed-88004582022-02-16 Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review Yarahmadi, Amir Azarpira, Negar Mostafavi-Pour, Zohreh Int J Mol Cell Med Mini Review The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine-protein kinase that senses and combines various environmental signals to regulate the growth and homeostasis of human cells. This signaling pathway synchronizes many critical cellular processes and is involved in an increasing number of pathological conditions such as diabetes, cancer, obesity, and metabolic syndrome. Here, we review different complications of diabetes that are associated with mTOR complex 1 imbalance. We further discuss pharmacological approaches to treat diabetes complications linked to mTOR deregulation. Babol University of Medical Sciences 2021 2022-01-10 /pmc/articles/PMC8800458/ /pubmed/35178356 http://dx.doi.org/10.22088/IJMCM.BUMS.10.3.181 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini Review
Yarahmadi, Amir
Azarpira, Negar
Mostafavi-Pour, Zohreh
Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review
title Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review
title_full Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review
title_fullStr Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review
title_full_unstemmed Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review
title_short Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review
title_sort role of mtor complex 1 signaling pathway in the pathogenesis of diabetes complications; a mini review
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800458/
https://www.ncbi.nlm.nih.gov/pubmed/35178356
http://dx.doi.org/10.22088/IJMCM.BUMS.10.3.181
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