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Methionine oxidation of CLK4 promotes the metabolic switch and redox homeostasis in esophageal carcinoma via inhibiting MITF selective autophagy

BACKGROUND: Metabolic reprogramming and redox homeostasis contribute to esophageal squamous cell carcinoma (ESCC). CDC‐like kinase 4 (CLK4) is a dual‐specificity kinase that can phosphorylate substrates’ tyrosine or serine/threonine residue. However, the role and mechanism of CLK4 in ESCC remain unk...

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Detalles Bibliográficos
Autores principales:	Shen, Yaxing, Zhang, Heng, Yao, Shihua, Su, Feng, Wang, Hao, Yin, Jun, Fang, Yong, Tan, Lijie, Zhang, Kaiguang, Fan, Xiangshan, Zhong, Ming, Zhou, Qingxin, He, Jie, Zhang, Zhiyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800482/ https://www.ncbi.nlm.nih.gov/pubmed/35092699 http://dx.doi.org/10.1002/ctm2.719

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