Cargando…
The regulatory subunits of PI3K, p85α and p85β, differentially affect BRD7-mediated regulation of insulin signaling
Bromodomain-containing protein 7 (BRD7) has been shown to interact with the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), p85, in the insulin signaling pathway. Here, we show that upregulation of hepatic BRD7 improves glucose homeostasis even in the absence of either p85 isoform, p85α...
Autores principales: | Lee, Junsik M, Liu, Renyan, Park, Sang Won |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800525/ https://www.ncbi.nlm.nih.gov/pubmed/34751372 http://dx.doi.org/10.1093/jmcb/mjab073 |
Ejemplares similares
-
Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β
por: Ito, Yoshihiro, et al.
Publicado: (2017) -
The p85 Regulatory Subunit of PI3K Mediates cAMP-PKA and Insulin Biological Effects on MCF-7 Cell Growth and Motility
por: Di Zazzo, E., et al.
Publicado: (2014) -
Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K
por: Conley, Mary Ellen, et al.
Publicado: (2012) -
PI3K activation is enhanced by FOXM1D binding to p110 and p85 subunits
por: Wang, Qi, et al.
Publicado: (2020) -
Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit
por: Shriver, Marey, et al.
Publicado: (2016)