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Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy

As a serious cardiovascular complication, diabetic cardiomyopathy (DCM) refers to diabetes-related changes in myocardial structure and function, which is obviously different from those cardiomyopathy secondary to hypertension, coronary heart disease, and valvular disease. The clinical features of DC...

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Autores principales: Tang, Zhaobing, Wang, Peng, Dong, Chao, Zhang, Juan, Wang, Xiong, Pei, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800599/
https://www.ncbi.nlm.nih.gov/pubmed/35103095
http://dx.doi.org/10.1155/2022/5913374
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author Tang, Zhaobing
Wang, Peng
Dong, Chao
Zhang, Juan
Wang, Xiong
Pei, Haifeng
author_facet Tang, Zhaobing
Wang, Peng
Dong, Chao
Zhang, Juan
Wang, Xiong
Pei, Haifeng
author_sort Tang, Zhaobing
collection PubMed
description As a serious cardiovascular complication, diabetic cardiomyopathy (DCM) refers to diabetes-related changes in myocardial structure and function, which is obviously different from those cardiomyopathy secondary to hypertension, coronary heart disease, and valvular disease. The clinical features of DCM are left ventricular hypertrophy, myocardial fibrosis, and impaired diastolic function. DCM will lead to cardiac dysfunction, eventually progress to cardiac arrhythmia, heart failure, and sudden cardiac death. At present, the pathogenesis of DCM is complex and not fully elucidated, and oxidative stress (OS), inflammatory response, glucolipid metabolism disorder, etc., are considered as the potential pathophysiological mechanisms. As a consequence, there is no specific and effective treatment for DCM. OS refers to the imbalance between reactive oxygen species (ROS) accumulation and scavenging, oxidation, and antioxidants in vivo, which is widely studied in DCM. Numerous studies have pointed out that regulating the OS signaling pathways and reducing the generation and accumulation of ROS are potential directions for the treatment of DCM. This review summarizes the major OS signaling pathways that are related to the pathogenesis of DCM, providing ideas about further research and therapy.
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spelling pubmed-88005992022-01-30 Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy Tang, Zhaobing Wang, Peng Dong, Chao Zhang, Juan Wang, Xiong Pei, Haifeng Oxid Med Cell Longev Review Article As a serious cardiovascular complication, diabetic cardiomyopathy (DCM) refers to diabetes-related changes in myocardial structure and function, which is obviously different from those cardiomyopathy secondary to hypertension, coronary heart disease, and valvular disease. The clinical features of DCM are left ventricular hypertrophy, myocardial fibrosis, and impaired diastolic function. DCM will lead to cardiac dysfunction, eventually progress to cardiac arrhythmia, heart failure, and sudden cardiac death. At present, the pathogenesis of DCM is complex and not fully elucidated, and oxidative stress (OS), inflammatory response, glucolipid metabolism disorder, etc., are considered as the potential pathophysiological mechanisms. As a consequence, there is no specific and effective treatment for DCM. OS refers to the imbalance between reactive oxygen species (ROS) accumulation and scavenging, oxidation, and antioxidants in vivo, which is widely studied in DCM. Numerous studies have pointed out that regulating the OS signaling pathways and reducing the generation and accumulation of ROS are potential directions for the treatment of DCM. This review summarizes the major OS signaling pathways that are related to the pathogenesis of DCM, providing ideas about further research and therapy. Hindawi 2022-01-22 /pmc/articles/PMC8800599/ /pubmed/35103095 http://dx.doi.org/10.1155/2022/5913374 Text en Copyright © 2022 Zhaobing Tang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tang, Zhaobing
Wang, Peng
Dong, Chao
Zhang, Juan
Wang, Xiong
Pei, Haifeng
Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy
title Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy
title_full Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy
title_fullStr Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy
title_full_unstemmed Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy
title_short Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy
title_sort oxidative stress signaling mediated pathogenesis of diabetic cardiomyopathy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800599/
https://www.ncbi.nlm.nih.gov/pubmed/35103095
http://dx.doi.org/10.1155/2022/5913374
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