Cargando…
Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy
As a serious cardiovascular complication, diabetic cardiomyopathy (DCM) refers to diabetes-related changes in myocardial structure and function, which is obviously different from those cardiomyopathy secondary to hypertension, coronary heart disease, and valvular disease. The clinical features of DC...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800599/ https://www.ncbi.nlm.nih.gov/pubmed/35103095 http://dx.doi.org/10.1155/2022/5913374 |
_version_ | 1784642296970477568 |
---|---|
author | Tang, Zhaobing Wang, Peng Dong, Chao Zhang, Juan Wang, Xiong Pei, Haifeng |
author_facet | Tang, Zhaobing Wang, Peng Dong, Chao Zhang, Juan Wang, Xiong Pei, Haifeng |
author_sort | Tang, Zhaobing |
collection | PubMed |
description | As a serious cardiovascular complication, diabetic cardiomyopathy (DCM) refers to diabetes-related changes in myocardial structure and function, which is obviously different from those cardiomyopathy secondary to hypertension, coronary heart disease, and valvular disease. The clinical features of DCM are left ventricular hypertrophy, myocardial fibrosis, and impaired diastolic function. DCM will lead to cardiac dysfunction, eventually progress to cardiac arrhythmia, heart failure, and sudden cardiac death. At present, the pathogenesis of DCM is complex and not fully elucidated, and oxidative stress (OS), inflammatory response, glucolipid metabolism disorder, etc., are considered as the potential pathophysiological mechanisms. As a consequence, there is no specific and effective treatment for DCM. OS refers to the imbalance between reactive oxygen species (ROS) accumulation and scavenging, oxidation, and antioxidants in vivo, which is widely studied in DCM. Numerous studies have pointed out that regulating the OS signaling pathways and reducing the generation and accumulation of ROS are potential directions for the treatment of DCM. This review summarizes the major OS signaling pathways that are related to the pathogenesis of DCM, providing ideas about further research and therapy. |
format | Online Article Text |
id | pubmed-8800599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-88005992022-01-30 Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy Tang, Zhaobing Wang, Peng Dong, Chao Zhang, Juan Wang, Xiong Pei, Haifeng Oxid Med Cell Longev Review Article As a serious cardiovascular complication, diabetic cardiomyopathy (DCM) refers to diabetes-related changes in myocardial structure and function, which is obviously different from those cardiomyopathy secondary to hypertension, coronary heart disease, and valvular disease. The clinical features of DCM are left ventricular hypertrophy, myocardial fibrosis, and impaired diastolic function. DCM will lead to cardiac dysfunction, eventually progress to cardiac arrhythmia, heart failure, and sudden cardiac death. At present, the pathogenesis of DCM is complex and not fully elucidated, and oxidative stress (OS), inflammatory response, glucolipid metabolism disorder, etc., are considered as the potential pathophysiological mechanisms. As a consequence, there is no specific and effective treatment for DCM. OS refers to the imbalance between reactive oxygen species (ROS) accumulation and scavenging, oxidation, and antioxidants in vivo, which is widely studied in DCM. Numerous studies have pointed out that regulating the OS signaling pathways and reducing the generation and accumulation of ROS are potential directions for the treatment of DCM. This review summarizes the major OS signaling pathways that are related to the pathogenesis of DCM, providing ideas about further research and therapy. Hindawi 2022-01-22 /pmc/articles/PMC8800599/ /pubmed/35103095 http://dx.doi.org/10.1155/2022/5913374 Text en Copyright © 2022 Zhaobing Tang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Tang, Zhaobing Wang, Peng Dong, Chao Zhang, Juan Wang, Xiong Pei, Haifeng Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy |
title | Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy |
title_full | Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy |
title_fullStr | Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy |
title_full_unstemmed | Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy |
title_short | Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy |
title_sort | oxidative stress signaling mediated pathogenesis of diabetic cardiomyopathy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800599/ https://www.ncbi.nlm.nih.gov/pubmed/35103095 http://dx.doi.org/10.1155/2022/5913374 |
work_keys_str_mv | AT tangzhaobing oxidativestresssignalingmediatedpathogenesisofdiabeticcardiomyopathy AT wangpeng oxidativestresssignalingmediatedpathogenesisofdiabeticcardiomyopathy AT dongchao oxidativestresssignalingmediatedpathogenesisofdiabeticcardiomyopathy AT zhangjuan oxidativestresssignalingmediatedpathogenesisofdiabeticcardiomyopathy AT wangxiong oxidativestresssignalingmediatedpathogenesisofdiabeticcardiomyopathy AT peihaifeng oxidativestresssignalingmediatedpathogenesisofdiabeticcardiomyopathy |