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Axial spondyloarthritis and inflammatory bowel disease: association between disease activity and endothelial dysfunction markers
OBJECTIVE: We aimed to assess patients with axial spondyloarthritis (axSpA) and inflammatory bowel disease (IBD) for disease activity and serum markers of endothelial dysfunction. METHODS: We studied 161 patients (123 males, 38 females) with axSpA: 153 with ankylosing spondylitis and 8 with non-radi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800891/ https://www.ncbi.nlm.nih.gov/pubmed/34240250 http://dx.doi.org/10.1007/s00296-021-04940-1 |
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author | Przepiera-Będzak, Hanna Fischer, Katarzyna Brzosko, Marek |
author_facet | Przepiera-Będzak, Hanna Fischer, Katarzyna Brzosko, Marek |
author_sort | Przepiera-Będzak, Hanna |
collection | PubMed |
description | OBJECTIVE: We aimed to assess patients with axial spondyloarthritis (axSpA) and inflammatory bowel disease (IBD) for disease activity and serum markers of endothelial dysfunction. METHODS: We studied 161 patients (123 males, 38 females) with axSpA: 153 with ankylosing spondylitis and 8 with non-radiographic axSpA, and 30 healthy controls (HC). We collected: age; sex; disease duration; extra-articular symptoms (IBD and acute anterior uveitis), comorbidities; human leukocyte antigen B27 status; and treatment. We measured serum interleukin (IL)-6, interleukin-18, IL-23, vascular endothelial growth factor (VEGF) epidermal growth factor (EGF), asymmetric dimethylarginine (ADMA), endothelin-1 (ET-1), and fetuin-A levels. RESULTS: IBD was diagnosed in 19 (11.8%) patients with axSpA. Compared to patients with axSpA without IBD, those with IBD had higher serum C-reactive protein (CRP) level (p = 0.05), erythrocyte sedimentation rate (ESR) (p = 0.005), and serum ET-1 levels (p = 0.01). In patients with axSpA and IBD, ET-1 levels correlated positively with CRP level (p = 0.006) and ESR (p = 0.02), and ADMA levels with visual analog scale scores (p = 0.01). Patients with axSpA and IBD had higher serum levels of IL-6 (p = 0.01), IL-18 (p = 0.005), and ADMA (p = 0.01) and lower serum levels of fetuin-A (p = 0.01) than did controls. CONCLUSIONS: Patients with axSpA and IBD had higher levels of disease activity, as assessed by ESR and CRP and ET-1 levels, than did patients with axSpA without IBD. Compared to HC, patients with axSpA and IBD had increased IL-18, ADMA levels and decreased fetuin-A level. |
format | Online Article Text |
id | pubmed-8800891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-88008912022-02-02 Axial spondyloarthritis and inflammatory bowel disease: association between disease activity and endothelial dysfunction markers Przepiera-Będzak, Hanna Fischer, Katarzyna Brzosko, Marek Rheumatol Int Observational Research OBJECTIVE: We aimed to assess patients with axial spondyloarthritis (axSpA) and inflammatory bowel disease (IBD) for disease activity and serum markers of endothelial dysfunction. METHODS: We studied 161 patients (123 males, 38 females) with axSpA: 153 with ankylosing spondylitis and 8 with non-radiographic axSpA, and 30 healthy controls (HC). We collected: age; sex; disease duration; extra-articular symptoms (IBD and acute anterior uveitis), comorbidities; human leukocyte antigen B27 status; and treatment. We measured serum interleukin (IL)-6, interleukin-18, IL-23, vascular endothelial growth factor (VEGF) epidermal growth factor (EGF), asymmetric dimethylarginine (ADMA), endothelin-1 (ET-1), and fetuin-A levels. RESULTS: IBD was diagnosed in 19 (11.8%) patients with axSpA. Compared to patients with axSpA without IBD, those with IBD had higher serum C-reactive protein (CRP) level (p = 0.05), erythrocyte sedimentation rate (ESR) (p = 0.005), and serum ET-1 levels (p = 0.01). In patients with axSpA and IBD, ET-1 levels correlated positively with CRP level (p = 0.006) and ESR (p = 0.02), and ADMA levels with visual analog scale scores (p = 0.01). Patients with axSpA and IBD had higher serum levels of IL-6 (p = 0.01), IL-18 (p = 0.005), and ADMA (p = 0.01) and lower serum levels of fetuin-A (p = 0.01) than did controls. CONCLUSIONS: Patients with axSpA and IBD had higher levels of disease activity, as assessed by ESR and CRP and ET-1 levels, than did patients with axSpA without IBD. Compared to HC, patients with axSpA and IBD had increased IL-18, ADMA levels and decreased fetuin-A level. Springer Berlin Heidelberg 2021-07-08 2022 /pmc/articles/PMC8800891/ /pubmed/34240250 http://dx.doi.org/10.1007/s00296-021-04940-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Observational Research Przepiera-Będzak, Hanna Fischer, Katarzyna Brzosko, Marek Axial spondyloarthritis and inflammatory bowel disease: association between disease activity and endothelial dysfunction markers |
title | Axial spondyloarthritis and inflammatory bowel disease: association between disease activity and endothelial dysfunction markers |
title_full | Axial spondyloarthritis and inflammatory bowel disease: association between disease activity and endothelial dysfunction markers |
title_fullStr | Axial spondyloarthritis and inflammatory bowel disease: association between disease activity and endothelial dysfunction markers |
title_full_unstemmed | Axial spondyloarthritis and inflammatory bowel disease: association between disease activity and endothelial dysfunction markers |
title_short | Axial spondyloarthritis and inflammatory bowel disease: association between disease activity and endothelial dysfunction markers |
title_sort | axial spondyloarthritis and inflammatory bowel disease: association between disease activity and endothelial dysfunction markers |
topic | Observational Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800891/ https://www.ncbi.nlm.nih.gov/pubmed/34240250 http://dx.doi.org/10.1007/s00296-021-04940-1 |
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