Blocking Short-Form Ron Eliminates Breast Cancer Metastases through Accumulation of Stem-Like CD4(+) T Cells That Subvert Immunosuppression

Immunotherapy has potential to prevent and treat metastatic breast cancer, but strategies to enhance immune-mediated killing of metastatic tumors are urgently needed. We report that a ligand-independent isoform of Ron kinase (SF-Ron) is a key target to enhance immune infiltration and eradicate metas...

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Detalles Bibliográficos
Autores principales: Lai, Shu-Chin Alicia, Gundlapalli, Harika, Ekiz, H. Atakan, Jiang, Amanda, Fernandez, Elvelyn, Welm, Alana L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800951/
https://www.ncbi.nlm.nih.gov/pubmed/34330779
http://dx.doi.org/10.1158/2159-8290.CD-20-1172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800951/
https://www.ncbi.nlm.nih.gov/pubmed/34330779
http://dx.doi.org/10.1158/2159-8290.CD-20-1172

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