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The effect of phytoestrogens (Cimicifuga racemosa) in combination with clomiphene in ovulation induction in women with polycystic ovarian syndrome: A clinical trial study

OBJECTIVE: Phytoestrogens can be used as an alternative to clomiphene for ovulation induction in patients with polycystic ovarian (PCO). In this study, we evaluated the impact of phytoestrogens (Cimicifuga racimosa) in combination with clomiphene on the endometrium thickness and follicle number in w...

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Autores principales: Pourhoseini, Seyedeh Azam, Mahmoudinia, Maliheh, Najaf Najafi, Mona, Kamyabi, Fouad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801214/
https://www.ncbi.nlm.nih.gov/pubmed/35145891
http://dx.doi.org/10.22038/AJP.2021.47998.2595
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author Pourhoseini, Seyedeh Azam
Mahmoudinia, Maliheh
Najaf Najafi, Mona
Kamyabi, Fouad
author_facet Pourhoseini, Seyedeh Azam
Mahmoudinia, Maliheh
Najaf Najafi, Mona
Kamyabi, Fouad
author_sort Pourhoseini, Seyedeh Azam
collection PubMed
description OBJECTIVE: Phytoestrogens can be used as an alternative to clomiphene for ovulation induction in patients with polycystic ovarian (PCO). In this study, we evaluated the impact of phytoestrogens (Cimicifuga racimosa) in combination with clomiphene on the endometrium thickness and follicle number in women with PCO. MATERIALS AND METHODS: This study was a prospective clinical trial conducted in the infertility research center of Milad Hospital in Mashhad, Iran, during 2016 and 2017 on 100 women with PCO syndrome. The patients were randomly divided into two equal groups. The patients in both groups were treated by clomiphene citrate 50 mg, twice a day for 5 days, from the second day of the menstrual cycle and for three consecutive cycle periods. The intervention group received Cimicifuga racemosa tablets 10 mg twice a day for 10 days from the second day of the menstrual cycle, in addition to the mentioned standard treatment. The two groups were compared in terms of the number and size of follicles and endometrial thickness on the ultrasound. RESULTS: There was no significant differences between the number of medium (p=0.288), large (p=0.086), and total (p=0.288) follicles between the two groups. Also, no significant difference was observed in endometrial thickness between the two groups (p=0.227). CONCLUSION: As a result, adding Cimicifuga racemosa to clomiphene could not increase the endometrial thickness and the number of follicles in PCO patients.  
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spelling pubmed-88012142022-02-09 The effect of phytoestrogens (Cimicifuga racemosa) in combination with clomiphene in ovulation induction in women with polycystic ovarian syndrome: A clinical trial study Pourhoseini, Seyedeh Azam Mahmoudinia, Maliheh Najaf Najafi, Mona Kamyabi, Fouad Avicenna J Phytomed Short Communication OBJECTIVE: Phytoestrogens can be used as an alternative to clomiphene for ovulation induction in patients with polycystic ovarian (PCO). In this study, we evaluated the impact of phytoestrogens (Cimicifuga racimosa) in combination with clomiphene on the endometrium thickness and follicle number in women with PCO. MATERIALS AND METHODS: This study was a prospective clinical trial conducted in the infertility research center of Milad Hospital in Mashhad, Iran, during 2016 and 2017 on 100 women with PCO syndrome. The patients were randomly divided into two equal groups. The patients in both groups were treated by clomiphene citrate 50 mg, twice a day for 5 days, from the second day of the menstrual cycle and for three consecutive cycle periods. The intervention group received Cimicifuga racemosa tablets 10 mg twice a day for 10 days from the second day of the menstrual cycle, in addition to the mentioned standard treatment. The two groups were compared in terms of the number and size of follicles and endometrial thickness on the ultrasound. RESULTS: There was no significant differences between the number of medium (p=0.288), large (p=0.086), and total (p=0.288) follicles between the two groups. Also, no significant difference was observed in endometrial thickness between the two groups (p=0.227). CONCLUSION: As a result, adding Cimicifuga racemosa to clomiphene could not increase the endometrial thickness and the number of follicles in PCO patients.   Mashhad University of Medical Sciences 2022 /pmc/articles/PMC8801214/ /pubmed/35145891 http://dx.doi.org/10.22038/AJP.2021.47998.2595 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Pourhoseini, Seyedeh Azam
Mahmoudinia, Maliheh
Najaf Najafi, Mona
Kamyabi, Fouad
The effect of phytoestrogens (Cimicifuga racemosa) in combination with clomiphene in ovulation induction in women with polycystic ovarian syndrome: A clinical trial study
title The effect of phytoestrogens (Cimicifuga racemosa) in combination with clomiphene in ovulation induction in women with polycystic ovarian syndrome: A clinical trial study
title_full The effect of phytoestrogens (Cimicifuga racemosa) in combination with clomiphene in ovulation induction in women with polycystic ovarian syndrome: A clinical trial study
title_fullStr The effect of phytoestrogens (Cimicifuga racemosa) in combination with clomiphene in ovulation induction in women with polycystic ovarian syndrome: A clinical trial study
title_full_unstemmed The effect of phytoestrogens (Cimicifuga racemosa) in combination with clomiphene in ovulation induction in women with polycystic ovarian syndrome: A clinical trial study
title_short The effect of phytoestrogens (Cimicifuga racemosa) in combination with clomiphene in ovulation induction in women with polycystic ovarian syndrome: A clinical trial study
title_sort effect of phytoestrogens (cimicifuga racemosa) in combination with clomiphene in ovulation induction in women with polycystic ovarian syndrome: a clinical trial study
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801214/
https://www.ncbi.nlm.nih.gov/pubmed/35145891
http://dx.doi.org/10.22038/AJP.2021.47998.2595
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