A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of the Monoclonal Antibody MHAA4549A in Patients With Acute Uncomplicated Influenza A Infection

BACKGROUND: MHAA4549A, a human monoclonal antibody targeting the influenza A hemagglutinin stalk, neutralizes influenza A virus in animal and human volunteer challenge studies. We investigated the safety and tolerability, efficacy, and pharmacokinetics of MHAA4549A in outpatients with acute, uncompl...

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Detalles Bibliográficos
Autores principales: Lim, Jeremy J, Dar, Sadia, Venter, Dirk, Horcajada, Juan P, Kulkarni, Priya, Nguyen, Allen, McBride, Jacqueline M, Deng, Rong, Galanter, Joshua, Chu, Tom, Newton, Elizabeth M, Tavel, Jorge A, Peck, Melicent C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801227/
https://www.ncbi.nlm.nih.gov/pubmed/35106315
http://dx.doi.org/10.1093/ofid/ofab630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801227/
https://www.ncbi.nlm.nih.gov/pubmed/35106315
http://dx.doi.org/10.1093/ofid/ofab630

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