Improved alpharetrovirus-based Gag.MS2 particles for efficient and transient delivery of CRISPR-Cas9 into target cells

DNA-modifying technologies, such as the CRISPR-Cas9 system, are promising tools in the field of gene and cell therapies. However, high and prolonged expression of DNA-modifying enzymes may cause cytotoxic and genotoxic side effects and is therefore unwanted in therapeutic approaches. Consequently, d...

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Detalles Bibliográficos
Autores principales: Baron, Yvonne, Sens, Johanna, Lange, Lucas, Nassauer, Larissa, Klatt, Denise, Hoffmann, Dirk, Kleppa, Marc-Jens, Barbosa, Philippe Vollmer, Keisker, Maximilian, Steinberg, Viviane, Suerth, Julia D., Vondran, Florian W.R., Meyer, Johann, Morgan, Michael, Schambach, Axel, Galla, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801357/
https://www.ncbi.nlm.nih.gov/pubmed/35141043
http://dx.doi.org/10.1016/j.omtn.2021.12.033

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