Delineating the activation mechanism and conformational landscape of a class B G protein-coupled receptor glucagon receptor

Class B G protein-coupled receptors (GPCRs) are important targets in the treatment of metabolic syndrome and diabetes. Although multiple structures of class B GPCRs–G protein complexes have been elucidated, the detailed activation mechanism of the receptors remains unclear. Here, we combine Gaussian...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Li, Mingyu, Liang, Wenqi, Shi, Xinchao, Fan, Jigang, Kong, Ren, Liu, Yaqin, Zhang, Jian, Chen, Ting, Lu, Shaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801358/
https://www.ncbi.nlm.nih.gov/pubmed/35140883
http://dx.doi.org/10.1016/j.csbj.2022.01.015

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