The Role of Progesterone Receptors in Breast Cancer

The progesterone receptor (PR) modulates estrogen receptors α (ERα) action in breast cancer; it is an upregulated target gene of ER, and its expression is dependent on estrogen. PR is also a valuable prognostic biomarker in breast cancer, especially in hormone-positive breast cancer. High expression...

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Detalles Bibliográficos
Autores principales: Li, Zhuo, Wei, Hongrui, Li, Siyan, Wu, Pei, Mao, Xiaoyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801368/
https://www.ncbi.nlm.nih.gov/pubmed/35115765
http://dx.doi.org/10.2147/DDDT.S336643
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author Li, Zhuo
Wei, Hongrui
Li, Siyan
Wu, Pei
Mao, Xiaoyun
author_facet Li, Zhuo
Wei, Hongrui
Li, Siyan
Wu, Pei
Mao, Xiaoyun
author_sort Li, Zhuo
collection PubMed
description The progesterone receptor (PR) modulates estrogen receptors α (ERα) action in breast cancer; it is an upregulated target gene of ER, and its expression is dependent on estrogen. PR is also a valuable prognostic biomarker in breast cancer, especially in hormone-positive breast cancer. High expression of PR is more frequently observed in tumors with a better baseline prognosis (ie, luminal A) than tumors with a poor baseline prognosis (ie, luminal B). In the following review, we present the role of PR in breast cancer, including the genomic characteristics and pathways in breast cancer, PR and endocrine therapy.
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spelling pubmed-88013682022-02-02 The Role of Progesterone Receptors in Breast Cancer Li, Zhuo Wei, Hongrui Li, Siyan Wu, Pei Mao, Xiaoyun Drug Des Devel Ther Review The progesterone receptor (PR) modulates estrogen receptors α (ERα) action in breast cancer; it is an upregulated target gene of ER, and its expression is dependent on estrogen. PR is also a valuable prognostic biomarker in breast cancer, especially in hormone-positive breast cancer. High expression of PR is more frequently observed in tumors with a better baseline prognosis (ie, luminal A) than tumors with a poor baseline prognosis (ie, luminal B). In the following review, we present the role of PR in breast cancer, including the genomic characteristics and pathways in breast cancer, PR and endocrine therapy. Dove 2022-01-26 /pmc/articles/PMC8801368/ /pubmed/35115765 http://dx.doi.org/10.2147/DDDT.S336643 Text en © 2022 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Li, Zhuo
Wei, Hongrui
Li, Siyan
Wu, Pei
Mao, Xiaoyun
The Role of Progesterone Receptors in Breast Cancer
title The Role of Progesterone Receptors in Breast Cancer
title_full The Role of Progesterone Receptors in Breast Cancer
title_fullStr The Role of Progesterone Receptors in Breast Cancer
title_full_unstemmed The Role of Progesterone Receptors in Breast Cancer
title_short The Role of Progesterone Receptors in Breast Cancer
title_sort role of progesterone receptors in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801368/
https://www.ncbi.nlm.nih.gov/pubmed/35115765
http://dx.doi.org/10.2147/DDDT.S336643
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