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Functional genetic dropout screens and in vivo validation of candidate therapeutic targets using mouse mammary tumoroids
We have previously developed 3D tumoroids derived from genetically engineered mouse models (GEMMs) of BRCA1/2-deficient breast cancer. Here, we describe how to genetically modify tumoroids, use them for functional genetic dropout screens, and carry out orthotopic transplantation of modified tumoroid...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801381/ https://www.ncbi.nlm.nih.gov/pubmed/35146447 http://dx.doi.org/10.1016/j.xpro.2022.101132 |