Nrf2 expands the intracellular pool of the chaperone AHSP in a cellular model of β-thalassemia

In β-thalassemia, free α-globin chains are unstable and tend to aggregate or degrade, releasing toxic heme, porphyrins and iron, which produce reactive oxygen species (ROS). α-Hemoglobin-stabilizing protein (AHSP) is a potential modifier of β-thalassemia due to its ability to escort free α-globin an...

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Detalles Bibliográficos
Autores principales: Han, Gaijing, Cao, Cong, Yang, Xi, Zhao, Guo-Wei, Hu, Xin-Jun, Yu, Dong-Lin, Yang, Rui-Feng, Yang, Ke, Zhang, Ying-Ying, Wang, Wen-Tian, Liu, Xiu-Zhen, Xu, Peng, Liu, Xue-Hui, Chen, Ping, Xue, Zheng, Liu, De-Pei, Lv, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801382/
https://www.ncbi.nlm.nih.gov/pubmed/35092867
http://dx.doi.org/10.1016/j.redox.2022.102239

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