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Inflammation-Induced Coagulopathy Substantially Differs Between COVID-19 and Septic Shock: A Prospective Observational Study
Critical COVID-19, like septic shock, is related to a dysregulated systemic inflammatory reaction and is associated with a high incidence of thrombosis and microthrombosis. Improving the understanding of the underlying pathophysiology of critical COVID-19 could help in finding new therapeutic target...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801505/ https://www.ncbi.nlm.nih.gov/pubmed/35111777 http://dx.doi.org/10.3389/fmed.2021.780750 |
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author | Dechamps, Mélanie De Poortere, Julien Martin, Manon Gatto, Laurent Daumerie, Aurélie Bouzin, Caroline Octave, Marie Ginion, Audrey Robaux, Valentine Pirotton, Laurence Bodart, Julie Gerard, Ludovic Montiel, Virginie Campion, Alessandro Gruson, Damien Van Dievoet, Marie-Astrid Douxfils, Jonathan Haguet, Hélène Morimont, Laure Derive, Marc Jolly, Lucie Bertrand, Luc Dumoutier, Laure Castanares-Zapatero, Diego Laterre, Pierre-François Horman, Sandrine Beauloye, Christophe |
author_facet | Dechamps, Mélanie De Poortere, Julien Martin, Manon Gatto, Laurent Daumerie, Aurélie Bouzin, Caroline Octave, Marie Ginion, Audrey Robaux, Valentine Pirotton, Laurence Bodart, Julie Gerard, Ludovic Montiel, Virginie Campion, Alessandro Gruson, Damien Van Dievoet, Marie-Astrid Douxfils, Jonathan Haguet, Hélène Morimont, Laure Derive, Marc Jolly, Lucie Bertrand, Luc Dumoutier, Laure Castanares-Zapatero, Diego Laterre, Pierre-François Horman, Sandrine Beauloye, Christophe |
author_sort | Dechamps, Mélanie |
collection | PubMed |
description | Critical COVID-19, like septic shock, is related to a dysregulated systemic inflammatory reaction and is associated with a high incidence of thrombosis and microthrombosis. Improving the understanding of the underlying pathophysiology of critical COVID-19 could help in finding new therapeutic targets already explored in the treatment of septic shock. The current study prospectively compared 48 patients with septic shock and 22 patients with critical COVID-19 regarding their clinical characteristics and outcomes, as well as key plasmatic soluble biomarkers of inflammation, coagulation, endothelial activation, platelet activation, and NETosis. Forty-eight patients with matched age, gender, and co-morbidities were used as controls. Critical COVID-19 patients exhibited less organ failure but a prolonged ICU length-of-stay due to a prolonged respiratory failure. Inflammatory reaction of critical COVID-19 was distinguished by very high levels of interleukin (IL)-1β and T lymphocyte activation (including IL-7 and CD40L), whereas septic shock displays higher levels of IL-6, IL-8, and a more significant elevation of myeloid response biomarkers, including Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) and IL-1ra. Subsequent inflammation-induced coagulopathy of COVID-19 also differed from sepsis-induced coagulopathy (SIC) and was characterized by a marked increase in soluble tissue factor (TF) but less platelets, antithrombin, and fibrinogen consumption, and less fibrinolysis alteration. In conclusion, COVID-19 inflammation-induced coagulopathy substantially differs from SIC. Modulating TF release and activity should be evaluated in critical COVID-19 patients. |
format | Online Article Text |
id | pubmed-8801505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88015052022-02-01 Inflammation-Induced Coagulopathy Substantially Differs Between COVID-19 and Septic Shock: A Prospective Observational Study Dechamps, Mélanie De Poortere, Julien Martin, Manon Gatto, Laurent Daumerie, Aurélie Bouzin, Caroline Octave, Marie Ginion, Audrey Robaux, Valentine Pirotton, Laurence Bodart, Julie Gerard, Ludovic Montiel, Virginie Campion, Alessandro Gruson, Damien Van Dievoet, Marie-Astrid Douxfils, Jonathan Haguet, Hélène Morimont, Laure Derive, Marc Jolly, Lucie Bertrand, Luc Dumoutier, Laure Castanares-Zapatero, Diego Laterre, Pierre-François Horman, Sandrine Beauloye, Christophe Front Med (Lausanne) Medicine Critical COVID-19, like septic shock, is related to a dysregulated systemic inflammatory reaction and is associated with a high incidence of thrombosis and microthrombosis. Improving the understanding of the underlying pathophysiology of critical COVID-19 could help in finding new therapeutic targets already explored in the treatment of septic shock. The current study prospectively compared 48 patients with septic shock and 22 patients with critical COVID-19 regarding their clinical characteristics and outcomes, as well as key plasmatic soluble biomarkers of inflammation, coagulation, endothelial activation, platelet activation, and NETosis. Forty-eight patients with matched age, gender, and co-morbidities were used as controls. Critical COVID-19 patients exhibited less organ failure but a prolonged ICU length-of-stay due to a prolonged respiratory failure. Inflammatory reaction of critical COVID-19 was distinguished by very high levels of interleukin (IL)-1β and T lymphocyte activation (including IL-7 and CD40L), whereas septic shock displays higher levels of IL-6, IL-8, and a more significant elevation of myeloid response biomarkers, including Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) and IL-1ra. Subsequent inflammation-induced coagulopathy of COVID-19 also differed from sepsis-induced coagulopathy (SIC) and was characterized by a marked increase in soluble tissue factor (TF) but less platelets, antithrombin, and fibrinogen consumption, and less fibrinolysis alteration. In conclusion, COVID-19 inflammation-induced coagulopathy substantially differs from SIC. Modulating TF release and activity should be evaluated in critical COVID-19 patients. Frontiers Media S.A. 2022-01-17 /pmc/articles/PMC8801505/ /pubmed/35111777 http://dx.doi.org/10.3389/fmed.2021.780750 Text en Copyright © 2022 Dechamps, De Poortere, Martin, Gatto, Daumerie, Bouzin, Octave, Ginion, Robaux, Pirotton, Bodart, Gerard, Montiel, Campion, Gruson, Van Dievoet, Douxfils, Haguet, Morimont, Derive, Jolly, Bertrand, Dumoutier, Castanares-Zapatero, Laterre, Horman and Beauloye. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Dechamps, Mélanie De Poortere, Julien Martin, Manon Gatto, Laurent Daumerie, Aurélie Bouzin, Caroline Octave, Marie Ginion, Audrey Robaux, Valentine Pirotton, Laurence Bodart, Julie Gerard, Ludovic Montiel, Virginie Campion, Alessandro Gruson, Damien Van Dievoet, Marie-Astrid Douxfils, Jonathan Haguet, Hélène Morimont, Laure Derive, Marc Jolly, Lucie Bertrand, Luc Dumoutier, Laure Castanares-Zapatero, Diego Laterre, Pierre-François Horman, Sandrine Beauloye, Christophe Inflammation-Induced Coagulopathy Substantially Differs Between COVID-19 and Septic Shock: A Prospective Observational Study |
title | Inflammation-Induced Coagulopathy Substantially Differs Between COVID-19 and Septic Shock: A Prospective Observational Study |
title_full | Inflammation-Induced Coagulopathy Substantially Differs Between COVID-19 and Septic Shock: A Prospective Observational Study |
title_fullStr | Inflammation-Induced Coagulopathy Substantially Differs Between COVID-19 and Septic Shock: A Prospective Observational Study |
title_full_unstemmed | Inflammation-Induced Coagulopathy Substantially Differs Between COVID-19 and Septic Shock: A Prospective Observational Study |
title_short | Inflammation-Induced Coagulopathy Substantially Differs Between COVID-19 and Septic Shock: A Prospective Observational Study |
title_sort | inflammation-induced coagulopathy substantially differs between covid-19 and septic shock: a prospective observational study |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801505/ https://www.ncbi.nlm.nih.gov/pubmed/35111777 http://dx.doi.org/10.3389/fmed.2021.780750 |
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