Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55–IL6ST Gene Region in Immature Dendritic Cells

Intronic single-nucleotide polymorphisms (SNPs) in the ANKRD55 gene are associated with the risk for multiple sclerosis (MS) and rheumatoid arthritis by genome-wide association studies (GWAS). The risk alleles have been linked to higher expression levels of ANKRD55 and the neighboring IL6ST (gp130)...

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Detalles Bibliográficos
Autores principales: Mena, Jorge, Alloza, Iraide, Tulloch Navarro, Raquel, Aldekoa, Ane, Díez García, Javier, Villanueva Etxebarria, Ane, Lindskog, Cecilia, Antigüedad, Alfredo, Boyero, Sabas, Mendibe-Bilbao, María del Mar, Álvarez de Arcaya, Amaya, Sánchez Menoyo, José Luis, Midaglia, Luciana, Villarrubia, Noelia, Malhotra, Sunny, Montalban, Xavier, Villar, Luisa María, Comabella, Manuel, Vandenbroeck, Koen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801523/
https://www.ncbi.nlm.nih.gov/pubmed/35111166
http://dx.doi.org/10.3389/fimmu.2021.816930

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