The Role and Application of Exosomes in Gastric and Colorectal Cancer

Gastric cancer and colorectal cancer are malignant tumors found in the human gastrointestinal tract. Bidirectional communication between tumor cells and their microenvironment can be realized through the transmission of exosomes—small, cell-derived vesicles containing complex RNA and proteins. Exoso...

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Autores principales: Li, Qirong, Wang, Dongxu, Ding, Dayong, Feng, Ye, Hou, Ruizhi, Liu, Dianfeng, Lin, Chao, Gao, Yongjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801572/
https://www.ncbi.nlm.nih.gov/pubmed/35111071
http://dx.doi.org/10.3389/fphar.2021.825475
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author Li, Qirong
Wang, Dongxu
Ding, Dayong
Feng, Ye
Hou, Ruizhi
Liu, Dianfeng
Lin, Chao
Gao, Yongjian
author_facet Li, Qirong
Wang, Dongxu
Ding, Dayong
Feng, Ye
Hou, Ruizhi
Liu, Dianfeng
Lin, Chao
Gao, Yongjian
author_sort Li, Qirong
collection PubMed
description Gastric cancer and colorectal cancer are malignant tumors found in the human gastrointestinal tract. Bidirectional communication between tumor cells and their microenvironment can be realized through the transmission of exosomes—small, cell-derived vesicles containing complex RNA and proteins. Exosomes play an important role in the proliferation, metastasis, immune response, and drug resistance of cancer cells. In this review, we focus on the role and application of exosomes in gastric and colorectal cancer. We also summarize the role of exosomes secreted by different types of cells in tumor development and as drug carriers in cancer treatment.
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spelling pubmed-88015722022-02-01 The Role and Application of Exosomes in Gastric and Colorectal Cancer Li, Qirong Wang, Dongxu Ding, Dayong Feng, Ye Hou, Ruizhi Liu, Dianfeng Lin, Chao Gao, Yongjian Front Pharmacol Pharmacology Gastric cancer and colorectal cancer are malignant tumors found in the human gastrointestinal tract. Bidirectional communication between tumor cells and their microenvironment can be realized through the transmission of exosomes—small, cell-derived vesicles containing complex RNA and proteins. Exosomes play an important role in the proliferation, metastasis, immune response, and drug resistance of cancer cells. In this review, we focus on the role and application of exosomes in gastric and colorectal cancer. We also summarize the role of exosomes secreted by different types of cells in tumor development and as drug carriers in cancer treatment. Frontiers Media S.A. 2022-01-17 /pmc/articles/PMC8801572/ /pubmed/35111071 http://dx.doi.org/10.3389/fphar.2021.825475 Text en Copyright © 2022 Li, Wang, Ding, Feng, Hou, Liu, Lin and Gao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Qirong
Wang, Dongxu
Ding, Dayong
Feng, Ye
Hou, Ruizhi
Liu, Dianfeng
Lin, Chao
Gao, Yongjian
The Role and Application of Exosomes in Gastric and Colorectal Cancer
title The Role and Application of Exosomes in Gastric and Colorectal Cancer
title_full The Role and Application of Exosomes in Gastric and Colorectal Cancer
title_fullStr The Role and Application of Exosomes in Gastric and Colorectal Cancer
title_full_unstemmed The Role and Application of Exosomes in Gastric and Colorectal Cancer
title_short The Role and Application of Exosomes in Gastric and Colorectal Cancer
title_sort role and application of exosomes in gastric and colorectal cancer
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801572/
https://www.ncbi.nlm.nih.gov/pubmed/35111071
http://dx.doi.org/10.3389/fphar.2021.825475
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