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The Effect of Body Adiposity and Alcohol Consumption on Serum Uric Acid: A Quantile Regression Analysis Based on the China National Health Survey

Adiposity and alcohol consumption are reported to be associated with a higher level of serum uric acid (SUA), but whether their effect differs on SUA percentile distribution is still unclear. In this study, we aimed to investigate how alcohol intake and body fat percentage (%BF) integrated with body...

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Autores principales: He, Huijing, Pan, Li, Ren, Xiaolan, Wang, Dingming, Du, Jianwei, Cui, Ze, Zhao, Jingbo, Wang, Hailing, Wang, Xianghua, Liu, Feng, Pa, Lize, Peng, Xia, Wang, Ye, Yu, Chengdong, Shan, Guangliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801605/
https://www.ncbi.nlm.nih.gov/pubmed/35111792
http://dx.doi.org/10.3389/fnut.2021.724497
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author He, Huijing
Pan, Li
Ren, Xiaolan
Wang, Dingming
Du, Jianwei
Cui, Ze
Zhao, Jingbo
Wang, Hailing
Wang, Xianghua
Liu, Feng
Pa, Lize
Peng, Xia
Wang, Ye
Yu, Chengdong
Shan, Guangliang
author_facet He, Huijing
Pan, Li
Ren, Xiaolan
Wang, Dingming
Du, Jianwei
Cui, Ze
Zhao, Jingbo
Wang, Hailing
Wang, Xianghua
Liu, Feng
Pa, Lize
Peng, Xia
Wang, Ye
Yu, Chengdong
Shan, Guangliang
author_sort He, Huijing
collection PubMed
description Adiposity and alcohol consumption are reported to be associated with a higher level of serum uric acid (SUA), but whether their effect differs on SUA percentile distribution is still unclear. In this study, we aimed to investigate how alcohol intake and body fat percentage (%BF) integrated with body mass index (BMI) influence the distribution of SUA in Chinese adults. Data from the China National Health Survey (CNHS) which included adults from 10 provinces of China were used (n = 31,746, aged 20–80 years, 40% male). %BF and BMI were integrated into eight expanded body composition groups to understand how excess body adiposity affects the distribution of SUA in the populational level. Self-report alcohol intake information was collected by face-to-face questionnaire interview. Quantile regression (QR) was used to analyze the data. We found that adiposity and alcohol consumption were associated with SUA, especially at the upper percentile in both sexes. In obese men, the QR coefficients at the 75th and 95th percentiles were 74.0 (63.1–84.9) and 80.9 (52.5–109.3) μmol/L, respectively. The highest quartile of %BF in men had a 92.6 (79.3–105.9) μmol/L higher SUA levels at its 95th percentile than the 5th quartile (p < 0.001). Compared with normal or underweight with the lowest %BF group (NWBF1), the obesity-highest %BF group (OBBF4) had the strongest positive effect on SUA, especially at the higher percentile of SUA. In BMI-defined normal or underweight participants, a higher quartile of %BF had greater effect size in all SUA percentiles. In men, current alcohol drinking had the strongest effect at the 95th percentile of SUA (QR coefficient: 31.8, with 95% CI: 22.6–41.0) comparing with 14.5, 95% CI of 8.4 to 20.6 in the 5th SUA percentile. High risk of alcohol consumption had a greater effect on SUA, especially in the higher SUA percentile. The observation of stronger association at the higher percentile of SUA suggests that decreasing body adiposity and alcohol intake at the populational level may shift the upper tails of the SUA distributions to lower values, thereby reducing the incidence of hyperuricemia.
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spelling pubmed-88016052022-02-01 The Effect of Body Adiposity and Alcohol Consumption on Serum Uric Acid: A Quantile Regression Analysis Based on the China National Health Survey He, Huijing Pan, Li Ren, Xiaolan Wang, Dingming Du, Jianwei Cui, Ze Zhao, Jingbo Wang, Hailing Wang, Xianghua Liu, Feng Pa, Lize Peng, Xia Wang, Ye Yu, Chengdong Shan, Guangliang Front Nutr Nutrition Adiposity and alcohol consumption are reported to be associated with a higher level of serum uric acid (SUA), but whether their effect differs on SUA percentile distribution is still unclear. In this study, we aimed to investigate how alcohol intake and body fat percentage (%BF) integrated with body mass index (BMI) influence the distribution of SUA in Chinese adults. Data from the China National Health Survey (CNHS) which included adults from 10 provinces of China were used (n = 31,746, aged 20–80 years, 40% male). %BF and BMI were integrated into eight expanded body composition groups to understand how excess body adiposity affects the distribution of SUA in the populational level. Self-report alcohol intake information was collected by face-to-face questionnaire interview. Quantile regression (QR) was used to analyze the data. We found that adiposity and alcohol consumption were associated with SUA, especially at the upper percentile in both sexes. In obese men, the QR coefficients at the 75th and 95th percentiles were 74.0 (63.1–84.9) and 80.9 (52.5–109.3) μmol/L, respectively. The highest quartile of %BF in men had a 92.6 (79.3–105.9) μmol/L higher SUA levels at its 95th percentile than the 5th quartile (p < 0.001). Compared with normal or underweight with the lowest %BF group (NWBF1), the obesity-highest %BF group (OBBF4) had the strongest positive effect on SUA, especially at the higher percentile of SUA. In BMI-defined normal or underweight participants, a higher quartile of %BF had greater effect size in all SUA percentiles. In men, current alcohol drinking had the strongest effect at the 95th percentile of SUA (QR coefficient: 31.8, with 95% CI: 22.6–41.0) comparing with 14.5, 95% CI of 8.4 to 20.6 in the 5th SUA percentile. High risk of alcohol consumption had a greater effect on SUA, especially in the higher SUA percentile. The observation of stronger association at the higher percentile of SUA suggests that decreasing body adiposity and alcohol intake at the populational level may shift the upper tails of the SUA distributions to lower values, thereby reducing the incidence of hyperuricemia. Frontiers Media S.A. 2022-01-17 /pmc/articles/PMC8801605/ /pubmed/35111792 http://dx.doi.org/10.3389/fnut.2021.724497 Text en Copyright © 2022 He, Pan, Ren, Wang, Du, Cui, Zhao, Wang, Wang, Liu, Pa, Peng, Wang, Yu and Shan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
He, Huijing
Pan, Li
Ren, Xiaolan
Wang, Dingming
Du, Jianwei
Cui, Ze
Zhao, Jingbo
Wang, Hailing
Wang, Xianghua
Liu, Feng
Pa, Lize
Peng, Xia
Wang, Ye
Yu, Chengdong
Shan, Guangliang
The Effect of Body Adiposity and Alcohol Consumption on Serum Uric Acid: A Quantile Regression Analysis Based on the China National Health Survey
title The Effect of Body Adiposity and Alcohol Consumption on Serum Uric Acid: A Quantile Regression Analysis Based on the China National Health Survey
title_full The Effect of Body Adiposity and Alcohol Consumption on Serum Uric Acid: A Quantile Regression Analysis Based on the China National Health Survey
title_fullStr The Effect of Body Adiposity and Alcohol Consumption on Serum Uric Acid: A Quantile Regression Analysis Based on the China National Health Survey
title_full_unstemmed The Effect of Body Adiposity and Alcohol Consumption on Serum Uric Acid: A Quantile Regression Analysis Based on the China National Health Survey
title_short The Effect of Body Adiposity and Alcohol Consumption on Serum Uric Acid: A Quantile Regression Analysis Based on the China National Health Survey
title_sort effect of body adiposity and alcohol consumption on serum uric acid: a quantile regression analysis based on the china national health survey
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801605/
https://www.ncbi.nlm.nih.gov/pubmed/35111792
http://dx.doi.org/10.3389/fnut.2021.724497
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